Multitarget-directed bio-inorganic hybrid structure
Provided herein is a multitarget-directed bio-inorganic hybrid structure. The hybrid structure is based on carbon nanotubes, and includes: carbon nanotubes; and two or more peptides bound to a surface of the carbon nanotubes and each independently interacting with different target molecules.
1. A hybrid structure comprising:
carbon nanotubes; and
a first self-assembling peptide and a second self-assembling peptide, both bound to a surface of the carbon nanotubes and each independently binding different target molecules;
wherein the first and second self-assembling peptides each comprise a self-assembly domain;
and wherein:
the first self-assembling peptide comprises an arginine rich motif (ARM) comprising the amino acid sequence of SEQ ID NO: 1 (TRQARRNRRRRWRR);
the second self-assembling peptide comprises a nuclear export signal (NES) comprising the amino acid sequence of SEQ ID NO: 2 (CLPPLERLTR); and
the self-assembly domain comprises the amino acid sequence of SEQ ID NO: 4 (KFEFKFEF).
2. A composition for inhibiting a multimolecular complex, the composition comprising the hybrid structure according to claim 1 .