Hand disinfectant
The invention provides a skin disinfectant for treating skin with eczema, preventing bacterial proliferation, and removing biofilm. Compositions of the invention include hypochlorous acid, acetic acid, water, and one or more additives or excipients. The formulation process removes metal ions, reduces ionic strength, controls pH, and reduces exposure to air, thus improving stability and lengthening shelf-life.
1. An air-free composition comprising:
hypochlorous acid (HOCl);
acetic acid (HAc) at a higher concentration than the HOCl;
water; and
an excipient comprising a thickening agent;
wherein the composition is made air-free by mixing in an air-free environment made air-free by degassing through reduced pressure and the HOCl and HAc are in concentrations that are not harmful to skin.
2. The composition of claim 1 , wherein the composition comprises a pH between 3.7 and 5.8.
3. The composition of claim 2 , wherein the composition comprises a pH of 4.76.
4. The composition of claim 3 , wherein the composition is titrated with NaOH and HAc.
5. The composition of claim 1 , wherein the water comprises purified water.
6. The composition of claim 1 , wherein the excipient comprises a substance selected from the group consisting of colloidal silica, synthetic clay materials, EDTA, polyethylene glycol, polysorbate, glycerol, acrylate copolymer, essential oils, buffers, cellulose derivatives, and xanthan gum.
7. The composition of claim 1 for use as a hand disinfectant.
8. A method for disinfecting skin, the method comprising applying to skin an air-free composition produced by mixing in an air-free environment made by degassing through reduced pressure, the composition comprising hypochlorous acid (HOCl), acetic acid (HAc) at a higher concentration than the HOCl, water, and an excipient; wherein the HOCl and HAc are in concentrations that are not harmful to skin.
9. The method of claim 8 , wherein the skin is broken or inflamed.
10. The method of claim 8 , further comprising breaking down a biofilm on the skin.
11. The method of claim 10 , wherein the biofilm is associated with a skin infection.
12. The method of claim 10 , wherein the biofilm is associated with eczema.
13. The method of claim 10 , wherein the biofilm is a Staphylococcus aureus biofilm.
14. The method of claim 8 , wherein the composition comprises a pH between 3.7 and 5.8.
15. The method of claim 14 , wherein the composition comprises a pH of 4.76.
16. The method of claim 15 , wherein the composition is titrated with NaOH and HAc.
17. The method of claim 8 , wherein the water comprises purified water.
18. The method of claim 8 , wherein the excipient comprises a thickening agent.
19. The method of claim 8 , wherein the excipient comprises a substance selected from the group consisting of colloidal silica, synthetic clay materials, EDTA, polyethylene glycol, polysorbate, glycerol, acrylate copolymer, essential oils, buffers, cellulose derivatives, and xanthan gum.