Sequences associated with TDP-43 proteinopathies and methods of using the same
The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
1. An oligonucleotide probe comprising a fragment of a TAR DNA-binding protein 43 (TDP-43) nucleotide sequence or a complement of the TDP-43 nucleotide sequence, wherein the fragment comprises fifteen to 200 contiguous nucleotides of (i) the TDP-43 nucleotide sequence of SEQ ID NO: 1 that includes nucleotide position 1077, wherein the fragment has an A at a position corresponding to nucleotide position 1077 of SEQ ID NO:1, or (ii) a sequence that is complementary to the TDP-43 nucleotide sequence of SEQ ID NO: 1 that includes nucleotide position 1077, wherein the fragment has a T at a position corresponding to nucleotide position 1077 of SEQ ID NO:1, and wherein the oligonucleotide probe is detectably labeled with a fluorescent, chemiluminescent, radioactive, colorimetric, and/or resonance label.
2. The oligonucleotide probe of claim 1 , wherein the probe comprises between 15 and 50 nucleotides.
3. An array comprising a substrate, wherein the substrate comprises the oligonucleotide probe of claim 1 .