IP Library Granted Patent US 10,690,739
Granted Patent B2
US 10,690,739 · App. 15/482,659 · Granted Jun 23, 2020

MRI RF pulse sequence for multidimensional outer volume suppression

Inventors: David Y Zeng (Stanford, CA); Dwight G Nishimura (Palo Alto, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
G01R33/4838G01R33/5602G01R33/5617
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Quick Facts
Patent No.
US 10,690,739
App. No.
15/482,659
Granted
Jun 23, 2020
Kind
B2
Abstract

A magnetic resonance imaging (MRI) techniques uses a T2-preparation outer volume suppression (OVS) pulse sequence to reduce the longitudinal magnetization outside a region of interest. A region is excited that includes the region of interest, radiofrequency (RF) signals are detected, and MRI images generated from the RF detected signals. The T2-preparation OVS pulse sequence includes, sequentially: a first tip-down excitation pulse, a first refocusing excitation pulse, a first tip-up excitation pulse that is selective spatially and/or spectrally, a second tip-down excitation pulse that is 180° out of phase with respect to the first tip-down excitation pulse, a second refocusing excitation pulse, and a second tip-up excitation pulse that is selective spatially and/or spectrally. Alternatively, the first tip-down excitation pulse is selective spatially and/or spectrally instead of the first tip-up excitation pulse, and the second tip-down excitation pulse is selective spatially and/or spectrally instead of the second tip-up excitation pulse.

Claims (14)

1. A method for magnetic resonance imaging (MRI) using a T2-preparation outer volume suppression (OVS) and fat suppression pulse sequence, the method comprising:

with an MRI apparatus, applying a T2-preparation OVS pulse sequence to reduce the longitudinal magnetization outside a region of interest (ROI);

and with the MRI apparatus, exciting a region that includes the region of interest, detecting from the region radiofrequency (RF) signals responsive to the excitation, and generating MRI images from the detected RF signals;

wherein the T2-preparation OVS pulse sequence comprises, sequentially:

a first half of the sequence comprising:

a first tip-down 90°, 90 60 180 60 composite excitation pulse,

a first 180° orthogonal hard refocusing excitation pulse,

a first tip-up spatially and spectrally selective −90° spatial sinc excitation pulse, and

a second half of the sequence comprising:

a second tip-down −90°, 90 60 180 60 composite excitation pulse that is an amplitude-negated version of the first tip-down 90° composite excitation pulse,

a second 180° orthogonal hard refocusing excitation pulse,

and a second tip-up spatially and spectrally selective 90° spatial sinc excitation pulse that is an amplitude-negated version of the first tip-up selective −90° spatial sinc excitation pulse.

2. The method of claim 1 wherein the first tip-up pulse is a spectral-spatial pulse with sinc envelope and sinc subpulses, and the second tip-up pulse is a spectral-spatial pulse with sinc envelope and sinc subpulses.

3. A non-transitory, tangible, computer-readable storage medium containing a program of instructions that cause an MRI scanner to implement the method of claim 1 .

Assignments (2)
CONFIRMATORY LICENSE Recorded May 17, 2017
From: STANFORD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042482/0216 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 8, 2017
From: ZENG, DAVID Y; NISHIMURA, DWIGHT G
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 041934/0877 →
Continuity (1)
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