Polyketides, methods of use and preparation
The invention is among others concerned with novel polyketides, their method of production, purification and use. The method can entail providing a bacterium that synthesizes the compound.
1. A compound of formula 1 or formula 2
wherein X can be an N, O or S atom wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 8 and R 9 are each independently aryl, acyl, methyl, C 2 -C 10 alkyl, C 3 -C 6 cycloalkyl, monosaccharide, polysaccharide with 2-5 consecutive saccharide rings, O, OH, N, NH, S, SH, hydrogen or an ether of the general formula —O—R 7 , wherein R 7 is methyl, ethyl or propyl; and R 6 is aryl, acyl, methyl, C 2 -C 10 alkyl, C 3 -C 6 cycloalkyl, monosaccharide, polysaccharide with 2-5 consecutive saccharide rings, O, OH, or hydrogen.
2. The compound according to claim 1 of formula 3 or 4
wherein X can be an N, O or S atom.
3. The compound according to claim 1 wherein R 1 , R 3 and R 4 are —OH; R 2 is —O—CH 3 ; R 5 is CH 3 ; and R 6 is hydrogen.
4. A composition comprising at least two compounds according to claim 1 , wherein one of said compounds is a compound of formula 1 and another of said compounds is a compound of formula 2.
5. A method for inhibiting growth of a micro-organism, cell or virus comprising culturing the micro-organism, the cell or the virus in the presence of an effective amount of a compound according to claim 1 .
6. A method for producing a compound according to claim 1 , comprising culturing a Streptomyces bacterium characterized in that the bacterium is of the strain deposited at the CBS under deposit number 138593.
7. The method of claim 6 , further comprising harvesting the compound.
8. A method for inhibiting the growth of a bacterium, a fungus or a eukaryotic cell comprising culturing the bacterium, the fungus or the eukaryotic cell in the presence of a growth inhibiting amount of a compound according to claim 1 .
9. A compound of the following: