Transcatheter prosthesis with sealing component, and systems and methods for delivering and deployment thereof

1. A system for delivering a transcatheter prosthesis comprising:

a prosthesis having a radially compressed configuration for delivery within a vasculature and a radially expanded configuration for deployment within a native anatomy comprising,

a frame, and

an elongate member encircling at least a first portion of the frame, wherein the elongate member is attached to the frame by at least one fixation member,

wherein a cross-section of the elongate member has an expanded outer diameter in a radially expanded state and a contracted outer diameter in a radially contracted state, the contracted outer diameter of the cross-section of the elongate member being less than the expanded outer diameter of the cross-section of the elongate member, and

wherein the elongate member in the radially expanded state provides a seal between the prosthesis and the native anatomy when the prosthesis is in the radially expanded configuration; and

a delivery catheter including an elongate cinching member encircling at least a second portion of the frame of the prosthesis, wherein the elongate cinching member is configured to hold at least the second portion of the frame of the prosthesis in the radially compressed configuration.

2. The system of claim 1 , wherein the at least one fixation member extends outwardly from an outer surface of the frame and the elongate member is slidable relative to the fixation member.

3. The system of claim 2 , wherein the elongate member is a resilient elongate member, the resilient elongate member having the radially contracted state when in tension and the radially expanded state when relaxed.

4. The system of claim 3 , wherein the resilient elongate member in the radially expanded state fills the at least one fixation member to extend the at least one fixation member outwardly, whereby the resilient elongate member and the at least one fixation member provide the seal between the prosthesis and the native anatomy when the prosthesis is in the radially expanded configuration.

5. The system of claim 4 , wherein the at least one fixation member comprises a plurality of fixation members spaced apart about a circumference of the frame, and the resilient elongate member is slidably disposed within the plurality of fixation members.

6. The system of claim 3 , wherein the resilient elongate member in the radially contracted state is configured to cinch or hold the first portion of the frame of the prosthesis in the radially compressed configuration for delivery.

7. The system of claim 1 , wherein the elongate member has a generally circular path about the frame.

8. A transcatheter prosthesis having a radially compressed configuration for delivery within a vasculature and a radially expanded configuration for deployment within a native anatomy, the prosthesis comprising:

a frame having a radially compressed configuration for delivery within a vasculature and a radially expanded configuration for deployment within a native anatomy;

a fixation member extending outwardly from an outer surface of the frame; and

an elongate member encircling at least a portion of the frame,

wherein a cross-section of the elongate member has an expanded outer diameter in a radially expanded state and a contracted outer diameter in a radially contracted state, the contracted outer diameter of the cross-section of the elongate member being less than the expanded outer diameter of the cross-section of the elongate member,

wherein the elongate member is slidably disposed within the fixation member, and

wherein the elongate member in the radially expanded state provides a seal between the prosthesis and the native anatomy when the prosthesis is in the radially expanded configuration.

9. The transcatheter prosthesis of claim 8 , wherein the elongate member is a resilient elongate member having the radially contracted state when in tension and the radially expanded state when relaxed.

10. The transcatheter prosthesis of claim 9 , wherein the resilient elongate member and the fixation member provide the seal between the prosthesis and the native anatomy when the prosthesis is in the radially expanded configuration and the resilient elongate member is in the radially expanded state.

11. The transcatheter prosthesis of claim 8 , wherein the elongate member has a generally circular path about the outer surface of the frame.

12. The transcatheter prosthesis of claim 8 , wherein the fixation member comprises a plurality of fixation members spaced apart about a circumference of the frame, and the elongate member is disposed within the plurality of fixation members.

13. The transcatheter prosthesis of claim 8 , wherein the prosthesis is a valve prosthesis, and the frame of the prosthesis includes a prosthetic valve component disposed within and secured to the frame.

14. A method of deploying and sealing a prosthesis within a native anatomy comprising:

loading a prosthesis with an elongate member onto a delivery catheter, wherein a cross-section of the elongate member has an expanded outer diameter in a radially expanded state and a contracted outer diameter in a radially contracted state, the contracted outer diameter of the cross-section of the elongate member being less than the expanded outer diameter of the cross-section of the elongate member, and wherein the elongate member encircles at least a portion of a frame of the prosthesis and provides a seal between the prosthesis and the native anatomy when the prosthesis is in a radially expanded configuration, and

wherein the elongate member is configured to axially elongate under tension to transition the elongate member from the radially expanded state to the radially contracted state; and

deploying the prosthesis in the radially expanded configuration at the native anatomy, wherein the elongate member seals between the prosthesis and the native anatomy to prevent blood flow therebetween.

15. The method of claim 14 , wherein the elongate member is a resilient elongate member configured to hold the prosthesis in the radially compressed configuration and the step of deploying the prosthesis includes releasing the resilient elongate member to permit the prosthesis to return to the radially expanded configuration.

16. The method of claim 14 , wherein the delivery catheter comprises an elongate cinching member configured to aid in holding at least a portion of the prosthesis in the radially compressed configuration, and wherein the step of deploying the prosthesis includes releasing and removing the elongate cinching member of the delivery catheter to permit the prosthesis to return to the radially expanded configuration.

17. The method of claim 16 , wherein the elongate member is a resilient elongate member configured to hold at least a portion of the prosthesis in the radially compressed configuration and the step of deploying the prosthesis further includes releasing the resilient elongate member to permit the prosthesis to return to the radially expanded configuration.

18. The method of claim 17 , wherein the resilient elongate member is configured to hold a first portion of the prosthesis in the radially compressed configuration and the elongate cinching member is configured to hold a second portion of the prosthesis in the radially compressed configuration, and

wherein releasing the resilient elongate member permits the first portion of the prosthesis to return to the radially expanded configuration, and

wherein releasing and removing the elongate cinching member of the delivery catheter permits the second portion of the prosthesis to return to the radially expanded configuration.

19. The method of claim 18 , wherein the prosthesis is a valve prosthesis and the native anatomy is a native heart valve.