Encapsulated cannabinoid formulations for oral delivery
Preparation of cannabinoid formulations containing: Δ9-tetrahydrocannabinol (Δ9-THC), Δ8-tetrahydrocannabinol (Δ8-THC), Δ9-tetrahydrocannabinolic acid (THCa), cannabidiol (CBD), cannabidiolic acid (CBDa), cannabigerol (CBG), cannabichromene (CBC) and cannabinol (CBN), either alone or in combinations henceforth known as Cannabis , have been created using an emulsification process to encapsulate cannabinoids. The aqueous-based method involves micellular encapsulation of cannabinoids, a method that has been used to increase the bioavailability of poorly permeable, lipophilic drugs. These preparations demonstrates the viability of sublingual, buccal, or oral delivery using an aqueous-based encapsulation method, including as a beverage or drink.
1. A cannabinoid composition for oral delivery, said composition comprising:
a cannabinoid preparation ranging from 0.001% to 3% (w/w);
at least one surfactant ranging from 2% to 15% (w/w);
at least one co-solvent ranging from 20% to 65% (w/w);
at least one flavoring composition ranging from 0.1% to 5% (w/w);
a preservative ranging from 0.01% to 5% (w/w); and
water ranging from 2% to 77% (w/w);
wherein said preparation is encapsulated by surfactants to form micelles having uni-, bi-, or multi-lamellar structures and yields the cannabinoid preparation capable of having increased bioavailability and operable for oral delivery.
2. The cannabinoid composition of claim 1 , wherein said composition is capable of oral, sublingual or buccal delivery.
3. The cannabinoid composition of claim 1 , wherein the at least one surfactant comprises two or more surfactants.
4. The cannabinoid composition of claim 3 , wherein the two or more surfactants comprise an HLB in the range of 1 to 8 and form a self-assembling emulsion.
5. The cannabinoid composition of claim 1 , wherein the at least one surfactant comprises an HLB in the range of 9-20.
6. The cannabinoid composition of claim 1 , wherein the at least one surfactant is selected from a group consisting of: oleic acid, sunflower oil, lecithin, phosphatidylcholine, isopropyl myristate, stearic acid, medium and long chain triglycerides (including Labrasol), polysorbate 20, polysorbate 80, or other ethoxylated surfactant, and sorbitan trioleate, other sorbitan surfactant, or combinations thereof.
7. The cannabinoid composition of claim 1 , wherein the at least one co-solvent is selected from a group consisting of: methanol, ethanol, isopropyl alcohol, butanol, pentanol, hexanol, ethylene glycol, glycerin, propylene glycol, dipropylene glycol, glycerol, erythritol, xylitol, mannitol, sorbitol, diethylene glycol monoethyl ether (Transcutol), any derivative thereof, and combinations relating thereto.
8. The cannabinoid composition of claim 1 , further comprising a stabilizer in the range of 0.01% to 3% (w/w).
9. The cannabinoid composition of claim 1 , further comprising a thickening agent in the range of 0.01% to 10% (w/w).
10. The cannabinoid composition of claim 1 , further comprising terpenes in the range of 0.1% to 5% (w/w).
11. A cannabinoid composition for consumption as a beverage, said composition comprising:
a first measured amount of a cannabinoid-containing suspension comprising:
a cannabinoid preparation ranging from 0.001% to 3% (w/w);
at least one surfactant ranging from 2% to 15% (w/w);
at least one co-solvent ranging from 20% to 65% (w/w);
at least one flavoring composition ranging from 0.1% to 5% (w/w);
a preservative ranging from 0.01% to 5% (w/w); and
water ranging from 2% to 77% (w/w); and
a liquid composition;
wherein said cannabinoid preparation is encapsulated by surfactants to form micelles having uni-, bi-, or multi-lamellar structures and yields the cannabinoid-containing suspension preparation capable of having increased bioavailability when consumed as a beverage.
12. The cannabinoid composition of claim 11 , wherein the at least one surfactant comprises two or more surfactants.
13. The cannabinoid composition of claim 12 , wherein the two or more surfactants comprise an HLB in the range of 1 to 8 and form a self-assembling emulsion.
14. The cannabinoid composition of claim 11 , wherein the at least one surfactant comprises an HLB in the range of 9-20.
15. The cannabinoid composition of claim 11 , wherein the at least one surfactant is selected from a group consisting of: oleic acid, sunflower oil, lecithin, phosphatidylcholine, isopropyl myristate, stearic acid, medium and long chain triglycerides (including Labrasol), polysorbate 20, polysorbate 80, or other ethoxylated surfactant, and sorbitan trioleate, other sorbitan surfactant, or combinations thereof.
16. The cannabinoid composition of claim 11 , wherein the at least one co-solvent is selected from a group consisting of: methanol, ethanol, isopropyl alcohol, butanol, pentanol, hexanol, ethylene glycol, propylene glycol, dipropylene glycol, glycerol, glycerin, erythritol, xylitol, mannitol, sorbitol, diethylene glycol monoethyl ether (Transcutol), any derivative thereof, and combinations relating thereto.
17. The cannabinoid composition of claim 11 , further comprising a stabilizer in the range of 0.01% to 3% (w/w).
18. The cannabinoid composition of claim 11 , further comprising a thickening agent in the range of 0.01% to 10% (w/w).
19. The cannabinoid composition of claim 11 , further comprising terpenes in the range of 0.1% to 5% (w/w).