Genetic markers for memory loss
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of a normal gene expression profile. A change in the value of the subject's gene expression profile, above or below normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
1. A method of treating a patient who has an increased risk of memory impairment, the method comprising
a) determining whether the patient has an increased risk of memory impairment by analyzing at least one sample from the patient prior to the onset of memory impairment to determine patient's gene expression levels of a set of genes, wherein the set of genes comprises SART3, SMARCB1, EXO1, CKAP2L, RGPD3, RBFOX2, SKIL, STYX, SORBS2, LYPLA1, CHGA, PXDNL, SGMS2, OBSCN, RAPGEF3, SPRY2, FAM98C, ABLIM3, MARCH4, SCLY, GATAD2A, STAG2, DTNA, HSD17B4 and PML and
b) administering a treatment for memory impairment to the patient when the patient is determined to have an increased risk of memory impairment;
wherein the patient is determined to have an increased risk of memory impairment when the patient's gene expression levels are altered from gene expression levels obtained from one or more subjects determined to define normal gene expression levels, wherein (i) the expression levels of the genes SART3, SMARCB1, EXO1, CKAP2L, RGPD2, RBFOX2, SORBS2, CHGA, PXDNL, RAPGEF3, MARCH4, GATAD2A are lower than normal gene expression levels, and (ii) the expression levels of the genes SKIL, STYX, LYPLA1, SGMS2, OBSCN, SPRY2, FAM98C, ABLIM3, SCLY, STAG2, DTNA, HSD17B4, PML are higher than normal gene expression levels.
2. The method of claim 1 , wherein the normal gene expression profile obtained from one or more subjects comprises the patient's gene expression profile prior to the onset of memory impairment and prior to analyzing the at least one sample in step (a).
3. The method of claim 1 , wherein the normal gene expression profile obtained from one or more subjects comprises a gene expression profile generated from a population of individuals that have never displayed memory impairment.
4. The method of claim 1 , wherein the treatment is administered to subject prior to the onset of any detectable signs of memory impairment in the patient.
5. The method of claim 1 , wherein the sample is a plasma sample.