Risperidone biodegradable implant
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
1. A biodegradable implant comprising:
a) a therapeutic drug present in an amount of 10-60% by mass relative to the mass of the implant, and
b) a polymer present in an amount of 40-90% by mass relative to the mass of the implant,
wherein the polymer comprises PLA and optionally PGA in a PLA:PGA molar ratio between 50:50 and 100:0;
wherein the therapeutic drug is risperidone;
wherein the implant is a shape suitable for tolerability in the subcutaneous space; and
wherein the mass of the implant is from 0.1-1.1 g.
2. The implant of claim 1 , wherein the risperidone is present at a concentration of 20-30% by mass relative to the mass of the implant.
3. The implant of claim 1 , wherein the polymer comprises PLA polymer.
4. The implant of claim 2 , wherein the polymer comprises PLA polymer.
5. The implant of claim 1 , wherein the polymer comprises PLGA polymer.
6. The implant of claim 2 , wherein the polymer comprises PLGA polymer.
7. The implant of claim 6 , wherein the PLGA has a molar ratio of lactic monomer to glycolic monomer of 80:20.
8. The implant of claim 6 , wherein the PLGA has a molar ratio of lactic monomer to glycolic monomer of 75:25.
9. The implant of claim 6 , wherein said PLGA has a molar ratio of lactic monomer to glycolic monomer of 65:35.
10. The implant of claim 1 , further comprising a pharmaceutically acceptable excipient.
11. The implant of claim 2 , further comprising a pharmaceutically acceptable excipient.
12. The implant of claim 2 , wherein the mass of the implant is from 0.1-0.3 g.
13. The implant of claim 2 , wherein the mass of the implant is from 0.5-1.0 g.
14. The implant of claim 2 , wherein the mass of the implant is from 0.6-0.8 g.