IP Library › Granted Patent US 10,738,095
Granted Patent B2
US 10,738,095 · App. 15/579,114 · Granted Aug 11, 2020

Engineered CCL20 locked dimer polypeptide

Inventors: Brian F. Volkman (Muskego, WI); Anthony E. Getschman (Wauwatosa, WI); Sam T. Hwang (Brookfield, WI); Yasutomo Imai (Milwaukee, WI); Francis C. Peterson (Racine, WI)
Assignee: The Medical College of Wisconsin, Inc.
C07K14/521A61K38/00
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Quick Facts
Patent No.
US 10,738,095
App. No.
15/579,114
Granted
Aug 11, 2020
Kind
B2
Abstract

The present invention provides a CCL20 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of psoriasis, inflammatory disorders and autoimmune disease.

Claims (6)

1. A CCL20 locked dimer polypeptide,

wherein the dimer comprises two monomers covalently linked together,

wherein each monomer is an amino acid sequence comprising SEQ ID NO: 1.

2. A composition comprising the CCL20 locked dimer polypeptide of claim 1 , and a pharmaceutically acceptable carrier or diluent.

3. The CCL20 dimer polypeptide of claim 1 , wherein the covalent link is a disulfide bond.

4. A kit comprising a CCL20 locked dimer polypeptide wherein the dimer comprises covalently linked monomers wherein the amino acid sequence of each monomer comprises SEQ ID NO:1, a pharmaceutically acceptable carrier or diluents and instructional material.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 14, 2019
From: MEDICAL COLLEGE OF WISCONSIN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 048069/0621 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2017
From: VOLKMAN, BRIAN F.; GETSCHMAN, ANTHONY E.; HWANG, SAM T.; IMAI, YASUTOMO; PETERSON, FRANCIS C.
To: THE MEDICAL COLLEGE OF WISCONSIN, INC.
Reel/Frame 044278/0229 →
Continuity (2)
Provisional Application 62170347 · Jun 3, 2015
Related Publication 20180237486A1 · Aug 23, 2018