Biodegradable supporting device
A biodegradable in vivo supporting device is disclosed. The in vivo supporting device comprises a biodegradable metal scaffold and a biodegradable polymer coating covering at least a portion of the biodegradable metal scaffold, wherein the biodegradable polymer coating has a degradation rate that is faster than the degradation rate of the biodegradable metal scaffold.
1. An in vivo supporting device, comprising:
a biodegradable metal scaffold; and
a biodegradable polymer coating covering at least a portion of said biodegradable metal scaffold,
wherein said biodegradable polymer coating has a thickness of 10-200 μm and a degradation rate that is different than the degradation rate of said biodegradable metal scaffold,
wherein said biodegradable metal scaffold comprises an alloy,
wherein the alloy comprises magnesium, manganese, and at least one rare earth metal,
wherein the biodegradable metal scaffold comprises metal struts,
wherein the biodegradable polymer coating partially covers the metal struts, but does not cover openings between the struts, and
wherein the struts from the biodegradable metal scaffold are fully encapsulated by the biodegradable polymer coating and the coated struts and openings therebetween are fully covered by the biodegradable polymer covering.
2. The in vivo supporting device of claim 1 , wherein said alloy has a magnesium content of 96-97.9 wt. %, a manganese content of 1.6-2 wt. %, and at least one rare earth metal in the amount of 0.5-2 wt. %.
3. The in vivo supporting device of claim 1 , wherein said biodegradable metal scaffold comprises metal struts, wherein said metal struts are covered by said biodegradable polymer coating, wherein said coating has one or more holes that allow direct contact of the metal strut with a body fluid when said supporting device is placed inside a body lumen.
4. The in vivo supporting device of claim 1 , further comprising a biodegradable polymer covering that covers the exterior surface of said metal scaffold, including openings between said metal struts.
5. The in vivo supporting device of claim 4 , wherein said covering comprises an agent that prevents or reduces the post-implantation hyperplastic response.
6. The in vivo supporting device of claim 1 , wherein the in vivo supporting device is a heart failure closure device for atrial septal defect (ASD), patent foramen ovale (PFO) or ventricular septal defect (VSD) or a device for fistula and aneurysm closures.
7. The in vivo supporting device of claim 1 , wherein said outer layer comprises a first agent that prevents or reduces the post-implantation hyperplastic response.
8. The in vivo supporting device of claim 7 , wherein said inner layer comprises a second agent that prevents or reduces the post-implantation hyperplastic response.
9. The in vivo supporting device of claim 1 , wherein said biodegradable metal scaffold is a self-expandable scaffold that expands after implantation and wherein said biodegradable polymer coating is an elastic coating that expands with said biodegradable metal scaffold.
10. The in vivo supporting device of claim 1 , wherein said biodegradable polymer coating comprises an agent that prevents or reduces the post-implantation hyperplastic response.
11. The in vivo supporting device of claim 1 , wherein said biodegradable metal scaffold is a self-expandable scaffold that expands after implantation and wherein said biodegradable polymer coating is a coating that forms fissures when said biodegradable metal scaffold is expands in vivo.
12. The in vivo supporting device of claim 11 , wherein said biodegradable polymer coating is permeable to body fluid.
13. The in vivo supporting device of claim 1 , wherein said biodegradable metal scaffold constitutes less than 50 wt % of said supporting device.
14. The in vivo supporting device of claim 1 , wherein said supporting device comprises magnesium as a minor component.
15. The in vivo supporting device of claim 1 , wherein said biodegradable metal scaffold has a magnesium content that is less than 50 wt % of said supporting device.
16. The in vivo supporting device of claim 1 , wherein said biodegradable polymer coating comprises a biodegradable polymer and metal particles.
17. The in vivo supporting device of claim 16 , wherein said metal particles are nanoparticles.
18. The in vivo supporting device of claim 1 , wherein said biodegradable polymer is an elastic coating that allows the device to be used in non-conforming lesions.