Apparatus, systems and methods for intraoperative imaging
The disclosed apparatus, systems and methods relate to devices, systems and methods for intra-operative imaging.
1. A system for identifying and removing biological material, comprising:
an imager comprising an imaging surface;
a visualization system in electrical communication with the imager wherein;
the imager has an overall thickness of less than 1 mm, and
the visualization system is configured to visualize an optical tag that is an up converting nanoparticle conjugated to a protein.
2. The system of claim 1 , further comprising an optical filter.
3. The system of claim 2 , wherein the optical filter is an angle-insensitive filter.
4. The system of claim 1 , wherein the imaging surface is operationally integrated with a surgical tool.
5. The system of claim 1 , wherein the imager is flexible.
6. The system of claim 1 , wherein the imaging surface comprises a plurality of individual pixels.
7. The system of claim 1 , wherein the imager has an overall thickness of less than 0.5 mm.
8. The system of claim 1 , wherein the imager has an overall thickness of less than 0.3 mm.
9. The system of claim 1 , wherein the imager has an overall thickness of less than 0.1 mm.
10. The system of claim 1 , wherein the imager has an overall thickness of less than 100 μm.
11. The system of claim 1 , further comprising a broad-emission LED light source.
12. The system of claim 1 , wherein the imager is configured to function without the need for an optical waveguide or an optical filter.
13. The system of claim 1 , wherein the imager is constructed and arranged to directly illuminate a tissue surface.
14. The system of claim 1 , wherein the imaging surface comprises a plurality of individual pixels with nano-grids for angle selective imaging.
15. The system of claim 1 , wherein the tissue surface is illuminated directly through the imager and up converting optical tags re-emitted at a shorter wavelength which is detected by the imager.
16. The system of claim 1 , wherein the system is constructed and arranged for time-gated imaging.
17. The system of claim 1 , wherein the imager has an overall thickness of less than 50 μm.