Lipid scavenging in Ras cancers
Methods and compositions for treating Ras-related cancers are provided that involve targeting lipid scavenging. Methods and compositions for identifying and/or characterizing more or less responsive cancers are also provided.
1. A method for inhibiting growth of a Ras-driven cancer cell or hypoxic cell, the method comprising contacting the cell with one or more saturated fatty acids, wherein contacting the cell with one or more saturated fatty acids comprises administering a nutrient with an excess of saturated fatty acids relative to polyunsaturated fatty acids.
2. The method of claim 1 , wherein the polyunsaturated fatty acids in the nutrient comprise one or more omega-3 fatty acids.
3. The method of claim 1 , wherein the nutrient comprises a ratio of saturated fatty acids to polyunsaturated fatty acids of at least 30:1.
4. The method of claim 1 , wherein the nutrient comprises a ratio of saturated fatty acids to polyunsaturated fatty acids of at least 50:1.
5. The method of claim 1 , wherein the cell is a pancreatic cancer cell.
6. The method of claim 1 , wherein the cell is a lung cancer cell.
7. The method of claim 1 , wherein the cell is a hypoxic cell.
8. The method of claim 1 , wherein the cell is a cancer cell.
9. The method of claim 1 , wherein contacting the cell with one or more saturated fatty acids comprises contacting the cell with one or more lipids comprising one or more saturated fatty acid tails.
10. The method of claim 9 , wherein each of one or more of the lipids comprises a plurality of fatty acid tails.
11. The method of claim 9 , wherein the one or more lipids comprise phosphatidylcholine lipids.
12. The method of claim 11 , wherein the phosphatidylcholine lipids are PC (16:0, 18:1) lipids.
13. The method of claim 9 , wherein the one or more lipids comprise saturated lysolipids.
14. The method of claim 13 , wherein the saturated lysolipids are LPC (18:0) lipids.
15. The method of claim 1 , wherein the polyunsaturated fatty acids in the nutrient comprise omega-3 fatty acids in excess of omega-6 fatty acids.
16. The method of claim 1 , wherein the nutrient comprises a ratio of saturated fatty acids to polyunsaturated fatty acids of at least 2:1.
17. The method of claim 1 , wherein the nutrient comprises a ratio of saturated fatty acids to polyunsaturated fatty acids of at least 10:1.