Oral care compositions and methods of use

1. An oral care composition comprising:

a. from 0.01% to 1% bisabolol, based on the total weight of the composition;

b. zinc oxide present in an amount of from 0.75 to 1.25 wt % and zinc citrate present in an amount of from 0.25 to 1.0 wt % based on the total weight of the composition;

c. from 0.01% to 1 zingerone, based on the total weight of the composition; and

d. a source of stannous ions.

2. The oral care composition of claim 1 , wherein the zinc citrate is present in an amount of about 0.5 wt % and zinc oxide is present in an amount of about 1.0% based on the total weight of the composition.

3. The oral care composition of claim 1 , wherein the source of stannous ions is stannous fluoride.

4. The oral care composition of claim 1 further comprising synthetic amorphous precipitated abrasive silica in an amount of from 1%-25% by wt, based on the total weight of the composition.

5. The oral care composition of claim 1 further comprising:

a high cleaning silica in an amount of from 1%-15% by wt, based on the total weight of the composition; and/or

an effective amount of one or more alkali phosphate salts, based on the total weight of the composition.

6. The oral care composition of claim 1 further comprising:

citric acid and tribasic citrate ion, in an amount of from 0.1-3 wt. %, and citrate ion, in an amount of from 0.1-5 wt. %, based on the total weight of the composition; and/or

carboxymethyl cellulose in an amount of from 0.1 wt. %, based on the total weight of the composition.

7. The oral care composition of claim 1 further comprising:

an anionic surfactant, in an amount of from 0.5-5 wt. %, based on the total weight of the composition; and/or

an amphoteric surfactant, in an amount of from 0.5-5% wt %, based on the total weight of the composition.

8. The oral care composition of claim 1 , further comprising a PVM/MA copolymer, in an amount of from 0.1-5 wt. %, based on the total weight of the composition.

9. The oral care composition of claim 8 , wherein the PVM/MA copolymer is a Gantrez polymer.

10. The oral care composition of claim 1 , further comprising microcrystalline cellulose/sodium carboxymethylcellulose in an amount of from 0.1-5 wt. %, based on the total weight of the composition.

11. The oral care composition of claim 1 , further comprising one or both of polyethylene glycol in an amount of from 1-6%; and propylene glycol in an amount of from 1-6%, based on the total weight of the composition.

12. The oral care composition claim 1 , further comprising:

polyvinylpyrrolidone (PVP) in an amount of from 0.5-3 wt. %, based on the total weight of the composition; and/or

high cleaning silica in an amount of from 5%-10% wt. %, based on the total weight of the composition.

13. The oral care composition of claim 1 , further comprising from 5%-40% free water by weight, based on the total weight of the composition.

14. The oral care composition of claim 1 , further comprising one or more thickening agents.

15. The oral care composition of claim 1 , comprising:

i. about 0.1-0.3% bisabolol;

ii. about 0.1-0.3% zingerone;

iii. about 1.0% zinc oxide;

iv. about 0.5% zinc citrate; and

v. about 0.4%-0.5% stannous fluoride.

16. The oral care composition of claim 1 , comprising:

i. about 0.1-0.3% bisabolol;

ii. about 0.1-0.3% zingerone;

iii. about 1.0% zinc oxide;

iv. about 0.5% zinc citrate;

v. about 0.4%-0.5% stannous fluoride; and

vi. about 12% abrasive silica.

17. The oral care composition of claim 1 , wherein the oral composition may be any of the following oral compositions selected from the group consisting of: a toothpaste or a dentifrice, a mouthwash or a mouth rinse, a topical oral gel, a chewing gum, and a denture cleanser.

18. The oral care composition of claim 1 , wherein the composition is obtained or obtainable by combining the ingredients as set forth in any of the preceding compositions.

19. A method to improve oral health comprising applying an effective amount of the oral composition of claim 1 to the oral cavity of a subject in need thereof, wherein the method is effective to:

i. reduce or inhibit formation of dental caries,

ii. reduce, repair or inhibit early enamel lesions, as detected by quantitative light-induced fluorescence (QLF) or electrical caries measurement (ECM),

iii. reduce or inhibit demineralization and promote remineralization of the teeth,

iv. reduce hypersensitivity of the teeth,

v. reduce or inhibit gingivitis,

vi. promote healing of sores or cuts in the mouth,

vii. reduce levels of acid producing bacteria,

viii. to increase relative levels of arginolytic bacteria,

ix. inhibit microbial bio film formation in the oral cavity,

x. raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge,

xi. reduce plaque accumulation,

xii. treat dry mouth,

xiii. enhance systemic health, including cardiovascular health,

xiv. Whiten teeth,

xv. reduce erosion of the teeth,

xvi. immunize (or protect) the teeth against cariogenic bacteria and their effects, and/or

xvii. clean the teeth and oral cavity.