Stent
A stent is disclosed that has an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of the body to provide fluid communication between the proximal end and the distal end. The stent also has a central lumen open at the proximal and distal ends of the stent for the passage of a guide wire. A method for using the stent and a kit containing the stent are also disclosed.
1. A method of emplacing a stent in a subject in need thereof, comprising:
establishing an entry portal into a vessel, duct or lumen contiguous with a target site for stent placement;
advancing a guide wire through the entry portal and said vessel, duct or lumen contiguous to said target site;
advancing said stent along said guide wire to said target site, said stent comprising an elongated body composed of a bioabsorbable polymer having a proximal end, a distal end, two open spiral channels formed on the exterior surface of said body to provide fluid communication between said proximal end and said distal end and a central lumen open at the proximal and distal ends of the stent for the passage of the guide wire,
measuring body fluid flow rate along the stent and setting a predetermined optimal fluid flow rate between said proximal end and said distal end, and
adjusting a rotation rate of the spiral channels along the stent based on the predetermined optimal fluid flow rate,
wherein the central lumen is not in fluid communication with the two open spiral channels and wherein said two open spiral channels have a rotation rate of between about 1.5 and about 3.5 twists per inch; and
withdrawing the guide wire.
2. The method of claim 1 , wherein said two open spiral channels have a rotation rate of between about 1.5 and about 2.5 twists per inch.
3. The method of claim 1 , wherein said two open spiral channels have a rotation rate of at least about 2 twists per inch.
4. The method of claim 1 , wherein said two open spiral channels are on opposite sides on the exterior surface of said elongated body.
5. The method of claim 1 , wherein said elongated body further comprises an anti-migration device.
6. The method of claim 1 , wherein said elongated body further comprises a biological agent.
7. The method of claim 6 , wherein said biological agent is selected from the group consisting of chemotherapeutic agents, antimicrobial agents and gene transfer agents.
8. The method of claim 1 , wherein said stent has a pre-implantation diameter D pre and is in situ expandable upon absorption of a body fluid to a post-implantation diameter D post , wherein D post is greater than D pre .
9. The method of claim 1 , wherein said stent further comprises a radio-opaque substance.
10. The method of claim 1 , wherein said bioabsorbable polymer comprises PEG and p-dioxanone.
11. The method of claim 1 , wherein said bioabsorbable polymer comprises PPDO.
12. The method of claim 1 , wherein said bioabsorbable polymer comprises PLA, trimethylene carbonate and caprolactone.