Vascular microcatheter
View Patent ↗There is provided a microcatheter with a tapering wall thickness shaft having varying stiffness/flexibility along its length from proximal end near the medical practitioner to the distal end near the target site in the patient, such as with at least three segments. The shaft is prepared of a thermoplastic material having varying composition along its length. The distal end may be shaped according to the required use just prior to the medical procedure. The microcatheter is particularly adapted for the delivery of microspheric compositions for treatment of tumors or fibroids by embolization of peripheral blood vessels of the tumor or fibroid.
1. A method of conducting a medical procedure in the blood vessel of a patient comprising:
inserting a catheter into the femoral artery of a patient wherein said catheter comprises
a hub having a proximal and distal end;
a luer adapter disposed at the proximal end for connecting with medical equipment;
a shaft extending from the hub distal end, the shaft having a proximal end, a distal end, a length of at least 35 inches, and a lumen, the shaft comprising
at least a first segment and a second segment each providing a portion of the length of the shaft, the first and second segments each having an outer diameter, the first segment outer diameter larger than the second segment outer diameter and the first segment arranged proximal to the second segment;
at least three braid sections each providing a portion of the length of the shaft, the at least three braid sections comprising a first braid section at the proximal end with a winding pitch of 100-130 PPI, a second braid section between the proximal end and distal end with a winding pitch of 130-150 PPI, and a third braid section at the distal end with a winding pitch of 160-180 PPI;
an outer jacket overlying the at least three braid sections, the outer jacket having a plurality of regions each providing a portion of the length of the shaft, the plurality of regions having different Shore D hardness values and arranged such that a Shore D hardness value at the proximal end is greater than at the distal end, and the plurality of regions having different wall thickness and arranged such that a wall thickness at the proximal end is greater than at the distal end;
navigating the distal end of the catheter to a site of treatment in the blood vessel of a patient;
introducing a composition comprising hydrogel microspheres into the lumen of the shaft of the catheter, wherein at least a portion of the hydrogel microspheres have a diameter greater than a diameter of the lumen of the catheter, and wherein the hydrogel microspheres have a diameter in a range of 500-700 μm and are deformable and have a compression deformation ratio of at least 50%;
injecting the composition comprising hydrogel microspheres from the lumen into the blood vessel.
2. The method of claim 1 wherein the microspheres comprise a crosslinked copolymer of cellulose acetate and a hydrophilic polymer.
3. The method of claim 2 wherein the hydrophilic polymer is selected from a poly alkylene glycol, polysaccharide, glucosaminoglycan, and modified cellulose.
4. The method of claim 2 wherein the hydrophilic polymer is selected from hydroxymethyl cellulose, chitosan, amylose, cellulose acetate, and polyvinyl alcohol.
5. The method of claim 2 wherein the microsphere further comprises a dye.
6. The method of claim 2 wherein said composition comprises a therapeutic agent.
7. The method of claim 2 wherein the site of treatment is an artery in the liver, heart, kidney, or uterus.
8. The method of claim 2 wherein the site of treatment is a blood vessel in a tumor or fibroid.
9. The method of claim 2 further comprising injecting an anticoagulant.
10. The method of claim 2 wherein the microspheres comprise a fluoroscopic agent.
11. The method of claim 10 further comprising imaging blood vessels at the site of treatment.