IP Library › Granted Patent US 10,793,568
Granted Patent B2
US 10,793,568 · App. 16/327,791 · Granted Oct 6, 2020

Hormone receptor modulators for treating metabolic conditions and disorders

Inventors: Jianhua Chao (Fremont, CA); Rakesh Jain (Fremont, CA); Lily Hu (Fremont, CA); Jason Gustaf Lewis (Fremont, CA); Helene Baribault (Fremont, CA); Jeremy Caldwell (Fremont, CA)
Assignee: ARDELYX, INC.
C07D471/08C07D413/12C07D413/14C07D417/14C07D493/08C07F9/65583
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Quick Facts
Patent No.
US 10,793,568
App. No.
16/327,791
Granted
Oct 6, 2020
Kind
B2
Abstract

The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): (I), wherein L 1 , A, X 1 , X 2 , R 1 , R 2 , and R 3 are described herein.

Claims (9)

1. A compound of Formula (Ix):

or a salt thereof,

wherein:

L 1 is —(CH 2 ) p — and p is 1;

A is phenyl;

R 1 and R 2 are both a Cl;

R 3 is cyclopropyl;

R 4 is COOR 6a ; and

R 6a is H.

Continuity (3)
Provisional Application 62532983 · Jul 14, 2017
Provisional Application 62378625 · Aug 23, 2016
Related Publication 20190233420A1 · Aug 1, 2019
Cited By (1)
US 12,209,088