Deuterated analogs of pridopidine useful as dopaminergic stabilizers
The present invention provides novel deuterated analogs of Pridopidine, i.e. 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine. Pridopidine is a drug substance currently in clinical development for the treatment of Huntington's disease. In other aspects the invention relates to pharmaceutical compositions comprising a deuterated analog of Pridopidine of the invention, and to therapeutic applications of these analogs.
1. A deuterated analogs of 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine represented as the following Compound D2, Compound D4, and Compound D7:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising a therapeutically effective amount of a deuterated analog of 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine according to claim 1 , or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carder, excipient or diluent.
3. The deuterated analog of 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine according to claim 1 , or a pharmaceutically acceptable salt thereof, for use as a medicament.