Reducing post-operative adhesion formation with intraperitoneal glutamine
The present disclosure relates to a method of treating or reducing adhesions in the peritoneum of a patient in need thereof. The method includes performing adhesiolysis on one or more adhesions involving the patient's peritoneum and/or one or more tissues or organs in the patient's peritoneal cavity; and administering to the peritoneum or the peritoneal cavity of the patient an effective amount of a composition comprising at least one glutamine source. The glutamine source is selected from one or more of L-glutamine, physiologically acceptable salts of L-glutamine, and dipeptides comprising L-glutamine.
1. A method of treating or reducing adhesions in the peritoneum of a patient in need thereof, comprising:
(a) performing adhesiolysis on one or more adhesions involving the patient's peritoneum and/or one or more tissues or organs in the patient's peritoneal cavity; and
(b) administering to the peritoneum or the peritoneal cavity of the patient an effective amount of a composition comprising at least one glutamine source;
wherein the glutamine source is a dipeptide selected from alanyl-glutamine and glycyl-glutamine.
2. The method of claim 1 , wherein the dipeptide is alanyl-glutamine.
3. The method of claim 1 , wherein the glutamine residue of the dipeptide is at the C-terminus of the dipeptide.
4. The method of claim 3 , wherein the glutamine residue is L-glutamine.
5. The method of claim 1 , wherein the composition is selected from the group consisting of a liquid composition, a paste composition, and a gel composition.
6. The method of claim 5 , wherein the liquid composition is a sterile aqueous composition.
7. The method of claim 1 , wherein the composition is impregnated in a surgical material.
8. The method of claim 7 , wherein the surgical material is a mesh.
9. The method of claim 5 , wherein the gel composition is a hydrogel.