Asenapine-containing patch
The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.
1. A patch, comprising:
a backing; and
an adhesive layer laminated on one side of the backing,
wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base comprising a rubber adhesive base, one or more low molecular weight amine, present in an amount of 0.5 to 40% by weight mass, selected from the group consisting of monoethanolamine, diethanolamine, triethanolamine, isopropanolamine and diisopropanolamine, a tackifier resin, liquid paraffin and a fatty acid ester having 6 to 20 carbon atoms, the adhesive layer exhibiting an effect of suppressing reduction of adhesion following moisture absorption;
wherein the rubber adhesive base consists of styrene-isoprene-styrene block copolymer and polyisobutylene in a mass ratio ranging from 15:2 to 2:15.
2. A method of manufacturing a patch according to claim 1 comprising a backing and an adhesive layer laminated on one side of the backing, comprising:
mixing asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine to obtain an adhesive composition; and
laminating the adhesive composition on one side of the backing.