Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance
A drug containing, as an active ingredient, a compound represented by ALK inhibitors such as brigatinib, AP26113-analog, and AZD3463 has been found to be effective against a non-small cell lung cancer having a point mutation at C797S in EGFR which has acquired a resistance to chemotherapy agents. Further, the drug used in combination with an anti-EGFR antibody demonstrates a notable suppression effect on the tumor growth. The drug has a potential to be a therapeutic agent effective against a non-small cell lung cancer which is resistant to gefitinib, a first generation therapeutic agent and osimertinib, a third generation therapeutic agent.
1. A method for testing the efficacy of administering brigatinib for treating a patient having an EGFR gene mutations-positive non-small cell lung cancer, the method comprising steps of:
obtaining a sample from the patient;
testing the sample to detect a mutation at position 797 in EGFR; and
selecting the patient a C797S mutation as being responsive for administration of brigatinib.
2. The method according to claim 1 , wherein detection of the mutation at position 797 in EGFR comprises detection of a mutation in a nucleic acid and/or protein.
3. The method according to claim 2 , wherein
the detection of the mutation in the nucleic acid is carried out by PCR; and
the detection of the mutation in the protein is carried out by an antibody.