Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
1. A method for preparing a compound of formula (A):
or a salt thereof, comprising contacting a compound of formula (B):
with SOCl 2 under conditions sufficient to form a compound of formula (A) or a salt thereof.
2. The method of claim 1 , wherein the conditions sufficient to form a compound of formula (A) or a salt thereof comprise dichloromethane.
3. The method of claim 1 , further comprising preparing a compound of formula (B), wherein preparing a compound of formula (B) comprises contacting a compound of formula (C):
with a compound of formula (D):
under conditions sufficient to form a compound of formula (B).
4. The method of claim 3 , wherein the conditions sufficient to form a compound of formula (B) comprise Pd(dppf)Cl 2 .