IP Library › Granted Patent US 10,828,291
Granted Patent B2
US 10,828,291 · App. 15/877,050 · Granted Nov 10, 2020

Decreasing expression level of proteasome subunit genes by treating a human subject with a nitroxide

Inventor: Louis Habash (Irvine, CA)
A61K31/445A61K45/06A61P35/00
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Quick Facts
Patent No.
US 10,828,291
App. No.
15/877,050
Granted
Nov 10, 2020
Kind
B2
Abstract

Some embodiments disclosed herein include a method for decreasing gene expression of a gene. The methods can include identifying a human subject over the age of 35 and having an increase expression level of a gene associated with proteasome activity; and administering to the human subject an effective amount of a nitroxide antioxidant, whereby expression level of the gene is decreased.

Claims (19)

1. A method of decreasing expression level of a gene encoding a protein of a proteasome complex in a subject suffering from a viral infection, the method comprising:

identifying the subject as having an increased expression level of a gene encoding a protein of a proteasome complex, the increased expression level associated with viral infection, wherein the gene selected from the group consisting of Psma6, Psmd3, Psmb4 , Psmb5, Psmc6, Psme4,Psmd9, Psmd12, Psmd14, Psmd4, Psma2, Psmc2, Psmc3, Psmd13, Psma7, and Psmc4; and

administering an effective amount of 4-hydroxy-2,2,6,6-tetramethylpiperidine- 1-oxyl (TEMPOL) to the subject, whereby the expression level of the gene is decreased.

2. The method of claim 1 , wherein the gene is Psma6.

3. The method of claim 1 , wherein the gene is Psmd3.

4. The method of claim 1 , wherein the gene is Psmb4.

5. The method of claim 1 , wherein the gene is Psmb5.

6. The method of claim 1 , wherein the gene is Psmc6.

7. The method of claim 1 , wherein the gene is Psme4.

8. The method of claim 1 , wherein the gene is Psmd9.

9. The method of claim 1 , wherein the gene is Psmd12.

10. The method of claim 1 , wherein the gene is Psmd14.

11. The method of claim 1 , wherein the gene is Psmd4.

12. The method of claim 1 , wherein the gene is Psma2.

13. The method of claim 1 , wherein the gene is Psmc2.

14. The method of claim 1 , wherein the gene is Psmc3.

15. The method of claim 1 , wherein the gene is Psmd13.

16. The method of claim 1 , wherein the gene is Psma7.

17. The method of claim 1 , wherein the gene is Psmc4.

Continuity (1)
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Cited By (1)
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