Pharmaceutical use
The invention relates to the use of a pharmaceutical medication comprising an aromatase inhibitor, preferably a steroidal aromatase inactivator and an antioxidant as effective ingredients for the treatment of sex hormone-dependent diseases. Furthermore, the invention relates to a composition comprising an aromatase inhibitor/—inactivator and α-lipoic acid and/or extract of green tea containing polyphenols. The combination of an aromatase inhibitor and—inactivator and α-lipoic acid and/or extract of green tea containing polyphenols is particularly suitable for the treatment of sex hormone-dependent diseases as well as for the treatment of benign tumors such as e.g. lipomatoses as occurring in Madelung's disease.
1. A method for treating lipomatosis in a subject in need thereof, the method comprising treating the subject with an effective amount of a pharmaceutical medication comprising a steroidal aromatase-inactivator and an antioxidant, wherein the aromatase-inactivator is selected from the group consisting of 4-hydroxyandrostenedione, exemestane, 4-acetoxyandrostenedione, 5-a-androst-3-ene-17-one and 3-a,4-a-epoxy-5-a-androstane-17-one; and wherein the antioxidant is alpha lipoic acid.
2. The method according to claim 1 , wherein the amount of the antioxidant is at least 0.05 wt. % of the total composition.
3. The method according to claim 1 , wherein the steroidal aromatase-inactivator is present in a range of from 1.0-3.0 wt. % of the total composition.
4. The method according to claim 1 , wherein the antioxidant is present in a range of from 0.5-2.0 wt. % of the total composition.
5. The method according to claim 1 , wherein the lipomatosis is Madelung's disease (Multiple Symmetric Lipomatosis).
6. The method according to claim 1 , wherein the steroidal aromatase-inactivator is 4-hydroxyandrostenedione.
7. The method according to claim 1 , wherein the antioxidant is alpha-lipoic acid and the steroidal aromatase-inactivator is 4-hydroxyandrostenedione.
8. The method according to claim 1 , wherein the pharmaceutical medication is administered topically.
9. The method according to claim 1 , further comprising hyaluronic acid.
10. A method for treating lipomatosis in a subject in need thereof, the method comprising treating the subject with a effective amount of a pharmaceutical medication comprising 4-hydroxyandrostenedione and alpha lipoic acid.
11. The method according to claim 10 , wherein the amount of the alpha lipoic acid is at least 0.05 wt. % of the total composition.
12. The method according to claim 10 , wherein the 4-hydroxyandrostenedione is present in a range of from 1.0-3.0 wt. % of the total composition.
13. The method according to claim 10 , wherein the alpha lipoic acid is present in a range of from 0.5-2.0 wt. % of the total composition.
14. The method according to claim 10 , wherein the lipomatosis is Madelung's disease (Multiple Symmetric Lipomatosis).
15. The method according to claim 10 , wherein the pharmaceutical medication is administered topically.
16. The method according to claim 10 , further comprising hyaluronic acid.