Immunopotentiator potentiating tumor immunity or infection immunity
An object of the present invention is to provide an immunopotentiating agent for reducing Tregs (in particular, effector Tregs) and potentiating tumor immunity or infection immunity. Imatinib and/or a salt thereof has the action of reducing Tregs (in particular, effector Tregs) and potentiating tumor immunity or infection immunity, and can be used as an active ingredient for the immunopotentiating agent.
1. A method of treating a chronic myelogenous leukemia in a subject in need thereof, the method comprising:
administering to the subject an immunopotentiating agent comprising imatinib and/or a salt thereof as an active ingredient, and
administering to the subject Melan-A antigen, wherein the Melan-A antigen is administered subsequent to administering the immunopotentiating agent,
wherein there is a reduction in number of effector Tregs in the peripheral blood of the subject and wherein there is an increase in the number of CD8 + T cells specific to the antigen specific to chronic myelogenous leukemia, so that immunity against the chronic myelogenous leukemia in the subject is potentiated.
2. The method of claim 1 , further comprising:
counting regulatory T cells contained in peripheral blood collected from the subject with chronic myelogenous leukemia after receiving administration of the imunopotentiating agent and the Melan-A antigen, and
predicting therapeutic efficacy of the administering of the imunopotentiating agent and the Melan-A antigen based on the number of the regulatory T cells.
3. The testing method according to claim 2 , wherein effector regulatory T cells contained in the peripheral blood are counted, and the therapeutic efficacy of the administering of the imunopotentiating agent and the Melan-A antigen is predicted based on the number of the effector regulatory T cells.
4. The testing method according to claim 2 , wherein the testing method is for predicting whether a molecular genetic complete response will be achieved or not.