IP Library › Granted Patent US 10,844,079
Granted Patent B2
US 10,844,079 · App. 16/908,604 · Granted Nov 24, 2020

Spiro aromatic ring compound and application thereof

Inventors: Qiangang Zheng (Shanghai, CN); Ming Xu (Shanghai, CN); Qinglong Zeng (Shanghai, CN); Jing Li (Shanghai, CN); Hao Zhuge (Shanghai, CN)
Assignee: Etern Biopharma (Shanghai) Co., Ltd.
C07D519/00
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Quick Facts
Patent No.
US 10,844,079
App. No.
16/908,604
Granted
Nov 24, 2020
Kind
B2
Abstract

Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

Claims (3)

1. A compound, which is:

or a pharmaceutically acceptable salt thereof.

2. A compound, which is:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2020
From: ZHENG, QIANGANG; XU, MING; ZENG, QINGLONG; LI, JING; ZHUGE, HAO
To: ETERN BIOPHARMA (SHANGHAI) CO., LTD.
Reel/Frame 053737/0478 →
Priority Claims (1)
CN 2018 1 1314910 · Nov 6, 2018 · national
Continuity (2)
Continuation PCTCN2019115754 · Nov 5, 2019
Related Publication 20200317695A1 · Oct 8, 2020
Cited By (2)
US 12,281,118 US 12,441,743