Polymer substrate retinal patch coated with adhesives
Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.
1. A patch configured to repair damaged ocular tissue, comprising:
a polymer matrix comprising parylene-C and having a first substantially planar surface and a second substantially planar surface;
a first adhesive component disposed over the first substantially planar surface; and
a second adhesive component disposed over the second substantially planar surface,
wherein the first adhesive component comprises a plurality of disintegrins coupled with at least a portion of the first substantially planar surface of the polymer matrix;
wherein the patch is configured to be positioned between two tissue layers of an eye in a subject during surgical implantation to adhere the two tissue layers together,
wherein retinal damage comprises a retinal tear, hole, dialyses, or detachment, and
wherein positioning of the patch over or adjacent to the retinal damage comprises placing the first adhesive component in contact with a retina in a damaged region, wherein the patch stabilizes the retinal damage and initiates repair of damaged ocular tissue.
2. The patch of claim 1 , wherein the retinal damage comprises retinal detachment and wherein the patch is configured for implantation into subretinal space to reattach the retina to a choroid.
3. The patch of claim 2 , wherein the plurality of disintegrins exhibit high affinity for integrin subunits such as αIIb, αv, α5, β1, β3 and β5.
4. The patch of claim 1 wherein the second adhesive component comprises a disintegrin, fibronectin, laminin, collagen, vitronectin or elastin.
5. The patch of claim 1 , wherein the patch is fenestrated to facilitate oxygen and nutrient passage through the patch.
6. The patch of claim 1 , wherein the disintegrins comprise vicrostatin, contortrostatin, ADAM derived polypeptides, or combinations thereof.
7. A biocompatible patch, comprising:
a polymer matrix having a first substantially planar surface and a second substantially planar surface;
a first adhesive component disposed over the first substantially planar surface; and
a second adhesive component disposed over the second substantially planar surface,
wherein the first adhesive component and the second adhesive component are configured for surgical implantation between two tissue layers of an eye in a subject to adhere the two layers together.
8. The patch of claim 7 wherein the patch is configured for surgical implantation on ocular tissues, to adhere to ocular tears/breaks, or to reattach a retina to a posterior wall of a subject's eye.
9. The patch of claim 7 , wherein the polymer matrix is selected from the group consisting of polyimide, silicone, and parylene.
10. The patch of claim 9 , wherein the polymer matrix comprises parylene-C.
11. The patch of claim 7 , wherein the polymer matrix is a bio-erodible polymer selected from the group consisting of poly(caprolactone), poly(lactic acid), poly(glycolic acid), polyglactin, poly(lactic-co-glycolic acid), starch and collagen.
12. The patch of claim 7 , wherein the first adhesive component is a same type as, or optionally a different type from the second adhesive component.
13. The patch of claim 7 , wherein the first adhesive component, the second adhesive component, or both the first and second adhesive components comprise a reverse thermal polymer.
14. The patch of claim 13 , wherein the reverse thermal polymer comprises pNIPAM.
15. The patch of claim 7 , wherein the first adhesive component, the second adhesive component, or both the first and second adhesive components comprise a disintegrin, fibronectin, laminin, collagen, vitronectin or elastin.
16. The patch of claim 15 , wherein the first adhesive component and/or the second adhesive component comprises disintegrin, vicrostatin, contortrostatin, or ADAM derived polypeptides.
17. The patch of claim 15 , wherein the first adhesive component and/or the second adhesive component can be cleaved by one or more enzymes, wherein the one or more enzymes are selected from the group consisting of elastase, urokinase, plasmin and tissue plasminogen activator.
18. The patch of claim 7 , wherein the patch is configured for temporary attachment or optionally for permanent attachment.
19. The patch of claim 7 , wherein the patch, the first adhesive component, and the second adhesive component are configured for surgical implantation on ocular tissue, the ocular tissue being cornea, sclera, lens or retina.
20. The patch of claim 7 , wherein the first adhesive component, the second adhesive component, and the polymer matrix are the same type of adhesive, and wherein the polymer matrix self-assembles in situ.
21. The patch of claim 7 wherein the first adhesive component and the second adhesive component are absent from a portion of the polymer matrix so that the first adhesive component and the second adhesive component are configured to make contact with tissue surrounding a treatment site, without contacting an injury.
22. The patch of claim 7 wherein the first adhesive component and/or the second adhesive component are a polymeric adhesive.
23. The patch of claim 7 wherein the first adhesive component and/or the second adhesive component are poly(N-isopropylacrylamide).