IP Library › Granted Patent US 10,849,898
Granted Patent B2
US 10,849,898 · App. 16/709,874 · Granted Dec 1, 2020

Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas

Inventors: Jiangchun Xu (San Diego, CA); Robert Cho (Sunnyvale, CA); Aaron Nguyen (San Jose, CA)
Assignee: CELGENE QUANTICEL RESEARCH, INC.
A61K31/513A61K31/357A61K31/436A61K31/5377A61K31/551A61K31/5685A61K31/7048A61P35/00C07D401/04C07D401/14C07D405/14
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Quick Facts
Patent No.
US 10,849,898
App. No.
16/709,874
Granted
Dec 1, 2020
Kind
B2
Abstract

Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).

Claims (15)

1. A method for the treatment of human merkel cell carcinoma comprising administration to a patient in need thereof an effective amount of a compound having the structure of:

or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein the administration is oral administration.

3. The method of claim 1 , wherein the effective amount of the compound comprises about 1.5 mg/kg to about 10 mg/kg.

4. The method of claim 1 , wherein the compound is combined with at least one pharmaceutically acceptable excipient.

5. The method of claim 1 , wherein the compound is in the form of a tablet, pill, sachet, or capsule of hard or soft gelatin.

6. The method of claim 5 , wherein the compound is in the form of a tablet.

7. The method of claim 5 , wherein the compound is in the form of a pill.

8. The method of claim 5 , wherein the compound is in the form of a sachet.

9. The method of claim 5 , wherein the compound is in the form of a hard gelatin capsule.

10. The method of claim 5 , wherein the compound is in the form of a soft gelatin capsule.

11. The method of claim 1 , wherein the compound is in the form of a capsule comprising the compound at dosage strengths of about 0.50 mg, about 0.75 mg, or about 2.00 mg.

12. The method of claim 11 , wherein the compound is in the form of a capsule comprising the compound at a dosage strength of about 0.50 mg.

13. The method of claim 11 , wherein the compound is in the form of a capsule comprising the compound at a dosage strength of about 0.75 mg.

14. The method of claim 11 , wherein the compound is in the form of a capsule comprising the compound at a dosage strength of about 2.00 mg.

Continuity (5)
Continuation 16387255 · Apr 17, 2019
Continuation 15673084 · Aug 9, 2017
Provisional Application 62373263 · Aug 10, 2016
Provisional Application 62468424 · Mar 8, 2017
Related Publication 20200113905A1 · Apr 16, 2020