Method for producing 3-hydroxyadipic acid
A novel method of producing 3-hydroxyadipic acid using a metabolic pathway of a microorganism is disclosed. The method of producing 3-hydroxyadipic acid includes the step of culturing at least one type of microorganism having a capacity to produce 3-hydroxyadipic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia, microorganisms belonging to the genus Pseudomonas, microorganisms belonging to the genus Hafnia, microorganisms belonging to the genus Corynebacterium, microorganisms belonging to the genus Bacillus, microorganisms belonging to the genus Streptomyces, microorganisms belonging to the genus Cupriavidus, microorganisms belonging to the genus Acinetobacter, microorganisms belonging to the genus Alcaligenes, microorganisms belonging to the genus Nocardioides, microorganisms belonging to the genus Brevibacterium, microorganisms belonging to the genus Delftia, microorganisms belonging to the genus Shimwellia, microorganisms belonging to the genus Aerobacter, and microorganisms belonging to the genus Rhizobium.
1. A method of producing 3-hydroxyadipic acid, said method comprising the steps of:
culturing in the presence of succinic acid at least one type of microorganism having a capacity to produce 3-hydroxyadipic acid, selected from the group consisting of microorganisms belonging to the genus Escherichia ,
wherein said microorganism(s) metabolize(s) succinic acid into 3-hydroxyadipic acid; and
recovering the produced 3-hydroxyadipic acid.
2. The method according to claim 1 , wherein said microorganism belonging to the genus Escherichia is Escherichia fergusonii or Escherichia coli.
3. The method according to claim 1 , wherein said microorganism is cultured with a medium containing at least one inducer selected from the group consisting of ferulic acid, p-coumaric acid, benzoic acid, cis,cis-muconic acid, protocatechuic acid, and catechol.