Skin care compositions and their applications
The present invention discloses a synergistic composition comprising 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids for use as a skin lightening agent. The invention also discloses a method of inhibiting melanin biosynthesis and tyrosinase activity in mammalian skin cells using a composition comprising 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids.
1. A method of inhibiting melanogenesis in mammalian skin cells, comprising a step of bringing into contact skin cells with a composition essentially consisting of 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids, to bring about a reduction in melanin synthesis, wherein the 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids are present in the concentrations of 0.5-500 μg/ml and 3-100 μg/ml respectively.
2. The method as in claim 1 , wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin, tetrahydrodemethoxycurcumin, tetrahydrobisdemethoxycurcumin.
3. The method as in claim 1 , wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin and tetrahydrodemethoxycurcumin.
4. The method as in claim 1 , wherein the tetrahydrocurcuminoids is greater than 95% w/w tetrahydrocurcumin.
5. The method as in claim 1 , wherein the mammalian skin cells are melanocytes.
6. The method as in claim 1 , wherein the mammal is human.
7. A method of inhibiting tyrosinase activity in mammalian skin cells, comprising a step of bringing into contact skin cells with a composition essentially consisting of 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids, to bring about a reduction in melanin synthesis, wherein the 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids are present in the concentrations of 0.5-500 μg/ml and 3-100 μg/ml respectively.
8. The method as in claim 7 , wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin, tetrahydrodemethoxycurcumin, tetrahydrobisdemethoxycurcumin.
9. The method as in claim 7 , wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin and tetrahydrodemethoxycurcumin.
10. The method as in claim 7 , wherein the tetrahydrocurcuminoids is greater than 95% w/w tetrahydrocurcumin.
11. The method as in claim 7 , wherein the mammalian skin cells are melanocytes.
12. The method as in claim 7 , wherein the mammal is human.