IP Library › Granted Patent US 10,864,373
Granted Patent B2
US 10,864,373 · App. 16/060,979 · Granted Dec 15, 2020

Systems for treatment of a neurological disorder using electrical nerve conduction block

Inventors: Niloy Bhadra (Cleveland, OH); Narendra Bhadra (Cleveland, OH); Kevin L. Kilgore (Cleveland, OH); Scott Lempka (Cleveland, OH); Jesse Wainright (Cleveland, OH); Tina Vrabec (Cleveland, OH); Manfred Franke (Cleveland, OH)
Assignee: CASE WESTERN RESERVE UNIVERSITY
A61N1/36071A61N1/0551A61N1/06A61N1/20A61N1/36021A61N1/36057A61N1/36103A61N1/36125A61N1/36171A61N1/36175
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Quick Facts
Patent No.
US 10,864,373
App. No.
16/060,979
Granted
Dec 15, 2020
Kind
B2
Abstract

One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the wave-form generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

Claims (15)

1. A system comprising:

a waveform generator to generate an electrical nerve conduction block (ENCB);

a controller coupled with the waveform generator, wherein the controller is configured to receive an input comprising at least one parameter to adjust the ENCB;

an electrical contact coupled with the waveform generator, wherein the electrical contact is configured to be placed into contact with a nerve, wherein the electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB;

wherein the electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

2. A system according to claim 1 , wherein the controller forms part of an open loop control system.

3. A system according to claim 2 , wherein the controller is configured to receive the input to adjust the ENCB from a user.

4. A system according to claim 1 , wherein the controller forms part of a closed loop control system.

5. A system according to claim 4 , wherein the controller is configured to receive the input to adjust the ENCB from an entity.

6. A system according to claim 5 , wherein the entity comprises a sensor configured to sense a change in a physiological parameter.

7. A system according to claim 2 , wherein the controller is configured to interpret the input and configured to signal the waveform generator including a parameter adjusted based on the input.

8. A system according to claim 7 , wherein the waveform generator is configured to generate an appropriate ENCB to be delivered to the nerve based on the adjusted parameter from the controller.

9. A system according to claim 1 , wherein, based on the input, the controller is configured to specify a timing parameter, an intensity parameter, a waveform parameter so that an appropriate ENCB is generated.

10. A system according to claim 1 , wherein the ENCB comprises at least one of a monophasic direct current (DC) waveform, a charge balanced direct current (CBDC) waveform, a substantially CBDC waveform, and a high frequency alternating current (HFAC) waveform.

11. A system according to claim 1 , wherein the waveform generator is configured to generate reversible ENCB so that when transmission of the ENCB is stopped, normal signal transmission through the nerve is restored.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 26, 2023
From: CASE WESTERN RESERVE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 064387/0738 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 7, 2018
From: BHADRA, NILOY; BHADRA, NARENDRA; KILGORE, KEVIN L.; VRABEC, TINA; FRANKE, MANFRED; LEMPKA, SCOTT; WAINRIGHT, JESSE
To: CASE WESTERN RESERVE UNIVERSITY
Reel/Frame 047705/0113 →
Continuity (2)
Continuation In Part 14969826 · Dec 15, 2015
Related Publication 20180361155A1 · Dec 20, 2018
Cited By (1)
US 12,201,837