Compounds for the treatment of cancer and inflammatory disease
Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory disease.
1. A compound of Formula VIIIb1:
or a pharmaceutically acceptable salt thereof,
wherein R 1b1 is 2-pyridyl;
R 8b1 is H;
R 9b1 is halo;
R 6b1 and R 7b1 are combined to form a cyclic structure including the nitrogen atom to which they are both attached.
2. A method of treating cancer, comprising administering to a subject the compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the cancer is a solid tumor, and said solid tumor is hepatocellular carcinoma, prostate cancer, pancreatic cancer, ovarian cancer, or glioblastoma.
3. The method of claim 2 , wherein the solid tumor is pancreatic cancer.
4. A method of treating an inflammatory disease, comprising administering to the compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the inflammatory disease is inflammatory bowel disease, Barrett's esophagus, asbestosis, gingivitis, pancreatitis, or bronchitis.
5. A pharmaceutical composition, comprising a therapeutically effective amount of the compound of Formula VIIIb1 of claim 1 and a pharmaceutically acceptable carrier.
6. The compound of claim 1 , wherein the compound is:
7. A pharmaceutical composition, comprising a therapeutically effective amount of the compound of claim 6 and a pharmaceutically acceptable carrier.