Anti-microbial compositions
A metal-EDTA compound/complex for combatting biofilms and/or treating wounds. The compound/complex comprises EDTA and from two to four metal ions. Of those two to four metal ions, at least two are different metal ions selected from Ag, Al, Au, Ba, Bi, Tl, Ce, Co, Cu, Fe, Ga, Ir, Mo, Rh, Ru, Ti, and Zn ions. The metal-EDTA compound/complex may exhibit any one or more of anti-microbial, anti-biofilm and anti-inflammatory activities in use and may increase the susceptibility of a biofilm and the microorganisms within said biofilm to attack by anti-microbial agents, helping to remove and sanitise the biofilm. A composition, wound dressing and medical device comprising the metal-EDTA complex are also provided. Uses of the metal-EDTA compound/complex as a medicament and/or to sanitise and/or substantially remove a biofilm from a substrate are also disclosed.
1. A compound of formula M n (EDTA); wherein:
n is an integer from 2 to 4;
each M is a metal ion; and
M n comprises at least two different metal ions selected from Ag, Al, Au, Ba, Bi, Tl, Ce, Co, Cu, Fe, Ga, Ir, Mo, Rh, Ru, Ti, and Zn ions.
2. The compound according to claim 1 , wherein n=3 or 4 and M n comprises two Ag ions.
3. The compound according to claim 1 , wherein M n comprises at least one Ag ion and one Zn ion.
4. The compound according to claim 3 , having the formula Ag 2 Zn(EDTA).
5. The compound according to claim 1 , wherein M n comprises at least one Ag ion and one Cu ion.
6. The compound according to claim 5 , having the formula Ag 2 Cu(EDTA).
7. A composition comprising one or more compounds according to claim 1 .
8. The composition according to claim 7 which is a hydrogel which comprises the one or more compounds.
9. The composition according to claim 7 , comprising fibres which are in contact with the one or more compounds.
10. The composition according to claim 7 , wherein the composition comprises a non-metal ion anti-microbial agent.
11. The composition according to claim 7 , wherein the composition comprises a surfactant.
12. A wound dressing comprising a compound according to claim 1 .
13. A medical device comprising a compound according to claim 1 .
14. A medicament comprising a compound according claim 1 .
15. A kit comprising a compound according to claim 1 and a medical device or wound dressing.
16. A wound dressing comprising a composition according to claim 7 .
17. A medical device comprising a composition according to claim 7 .
18. A medicament comprising a composition according to claim 7 .
19. A kit comprising a composition according to claim 7 and a medical device or a wound dressing.