IP Library › Granted Patent US 10,888,520
Granted Patent B2
US 10,888,520 · App. 13/701,619 · Granted Jan 12, 2021

Coated particle and method for producing coated particle

Inventors: Hideki Ichikawa (Hyogo, JP); Yoshinobu Fukumori (Hyogo, JP); Satoru Abe (Niigata-ken, JP); Yusuke Masue (Niigata-ken, JP)
Assignees: KOBE GAKUIN EDUCATIONAL FOUNDATION; NIPPON SODA CO., LTD.
A61K9/14A61K9/5026A61K9/5031A61K9/5047A61K9/5089A61K31/167
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Quick Facts
Patent No.
US 10,888,520
App. No.
13/701,619
Granted
Jan 12, 2021
Kind
B2
Abstract

The present invention relates to a coating particle containing a nuclear particle covered with a coating layer, and in the coating particle, the coating layer is a layer containing hydroxyalkyl cellulose and a binder.

Claims (15)

1. A coating particle comprising a nuclear particle covered with a coating layer, wherein the coating layer is a layer comprising hydroxyalkyl cellulose particles and a binder; and the nuclear particle has a volume average particle size of from 50 to 500 μm and the hydroxyalkyl cellulose particle has a volume average particle size of from 0.1 to 20 μm.

2. The coating particle according to claim 1 , wherein the binder is at least one selected from the group consisting of polyalkylene glycol, polyalkylene glycol higher fatty acid ester, higher fatty acid, higher alcohol, higher alcohol ester and natural wax.

3. The coating particle according to claim 1 , wherein the coating layer further comprises an elution controlling base and/or silica.

4. A method for producing a coating particle, comprising a first step of dry-coating a nuclear particle with hydroxyalkyl cellulose particles and a binder, wherein the nuclear particle has a volume average particle size of from 50 to 500 μm and the hydroxyalkyl cellulose particles has a volume average particle size of from 0.1 to 20 μm.

5. The method for producing a coating particle according to claim 4 , further comprising a second step of dry-coating the nuclear particle obtained in the first step with an elution controlling base and a binder.

6. The method for producing a coating particle according to claim 4 , further comprising a third step of overcoating the nuclear particle obtained in the first step with silica.

7. The method for producing a coating particle according to claim 4 , further comprising a second step of dry-coating the nuclear particle obtained in the first step with an elution controlling base and a binder, and a third step of overcoating the nuclear particle obtained in the second step with silica.

8. The coating particle according to claim 1 , wherein the coating layer comprises from 5 to 70% by weight of the hydroxyalkyl cellulose particles based on the coating particle.

9. The coating particle according to claim 1 , wherein the binder has a melting point of from 40 to 70° C.

10. The coating particle according to claim 1 , wherein the binder has a volume average particle size of from 1 to 100 μm.

11. The coating particle according to claim 1 , wherein the coating layer comprises from 0.1 to 20% by weight of the binder based on the coating particle.

12. The coating particle according to claim 1 , wherein the coating particle is prepared by a process comprising: a first step of dry-coating a nuclear particle with hydroxyalkyl cellulose particle and a binder.

13. The coating particle according to claim 12 , wherein the process further comprises a second step of dry-coating the particle obtained in the first step with an elution controlling base and a binder.

14. The coating particle according to claim 13 , wherein the process further comprises a third step of overcoating the particle obtained in the first step with silica.

15. The coating particle according to claim 12 , wherein the process further comprises a second step of dry-coating the particle obtained in the first step with an elution controlling base and a binder, and a third step of overcoating the particle obtained in the second step with silica.

Assignments (3)
NUNC PRO TUNC ASSIGNMENT Recorded Dec 16, 2022
From: KOBE GAKUIN EDUCATIONAL FOUNDATION
To: NIPPON SODA CO., LTD.
Reel/Frame 062118/0968 →
CHANGE OF ADDRESS Recorded Dec 16, 2022
From: KOBE GAKUIN EDUCATIONAL FOUNDATION
To: KOBE GAKUIN EDUCATIONAL FOUNDATION
Reel/Frame 062140/0885 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 3, 2012
From: ICHIKAWA, HIDEKI; FUKAMORI, YOSHINOBU; ABE, SATORU; MASUE, YUSUKE
To: KOBE GAKUIN EDUCATIONAL FOUNDATION; NIPPON SODA CO., LTD.
Reel/Frame 029392/0536 →
Priority Claims (1)
JP 2010-130663 · Jun 8, 2010 · national
Continuity (1)
Related Publication 20130071481A1 · Mar 21, 2013