Methods and agents for treating Alzheimer's disease
The present disclosure provides compositions and methods useful for treating or preventing diseases or disorders where beta amyloid accumulation or aggregation contributes to the pathology or symptomology of the disease, for example Alzheimer's disease.
1. A method of treating a neuro-inflammation disorder associated with beta amyloid accumulation in a subject, the method comprising administering to a subject in need thereof an effective amount of an anti-CD33 antibody that binds to a cell-surface receptor encoded by CD33 and inhibits or reduces the expression or activity of CD33 protein.
2. The method of claim 1 , wherein the neuro-inflammation disorder associated with beta amyloid accumulation is Alzheimer's disease or Lewy body dementia.
3. The method of claim 2 , wherein the neuro-inflammation disorder associated with beta amyloid accumulation is Alzheimer's disease.