Drug delivery particle formulations with targeting moieties
A targeted drug delivery complex containing a particle, a targeting moiety electrostatically attached to the particle, and an active pharmaceutical ingredient attached to or dispersed or dissolved within the particle is provided. Also provided are pharmaceutical formulations containing a plurality of the complexes as well as methods for use in targeting an active pharmaceutical ingredient to a selected cell or tissue and production of such formulations.
1. A targeted drug delivery complex comprising a particle, a targeting moiety attached electrostatically to the particle, and an active pharmaceutical ingredient dispersed or dissolved with or attached to the particle, wherein the targeting moiety and the active pharmaceutical ingredient are not covalently modified, wherein the particle is made of a matrix comprising cetylpyridinium bromide and a lipid, natural polymer and/or synthetic polymer, and wherein the targeting moiety is selected from an antibody or a Fab.
2. The targeted drug delivery complex of claim 1 wherein the targeting moiety binds to a selected cell or tissue.
3. The targeted drug delivery complex of claim 1 wherein the active pharmaceutical ingredient is selected from the group comprising analgesics, anti-anginal agents, anti-asthmatics, anti-arrhythmic agents, anti-angiogenic agents, antibacterial agents, anti-benign prostate hypertrophy agents, anti-cystic fibrosis agents, anti-coagulants, anti-depressants, anti-diabetic agents, anti-epileptic agents, anti-fungal agents, anti-gout agents, anti-hypertensive agents, anti-inflammatory agents, anti-malarial agents, anti-migraine agents, anti-muscarinic agents, anti-neoplastic agents, anti-obesity agents, anti-osteoporosis agents, anti-parkinsonian agents, anti-protozoal agents, anti-thyroid agents, anti-urinary incontinence agents, anti-viral agents, anxiolytics, beta-blockers, cardiac inotropic agents, cognition enhancers, corticosteroids, COX-2 inhibitors, diuretics, erectile dysfunction improvement agents, essential fatty acids, gastrointestinal agents, histamine receptor antagonists, hormones, immunosuppressants, keratolyptics, leukotriene antagonists, lipid regulating agents, macrolides, muscle relaxants, non-essential fatty acids, nutritional agents, nutritional oils, protease inhibitors and stimulants.
4. The targeted drug delivery complex of claim 1 wherein the active pharmaceutical ingredient is dissolved, in a liquid or solid solution, in the particle matrix and/or dispersed within the particle matrix and/or adhered to a particle surface.
5. A pharmaceutical formulation comprising a plurality of targeted drug delivery complexes of claim 1 and a pharmaceutically acceptable vehicle.