Ameliorating agent for exercise-induced gastrointestinal disorders
Ingesting an agent containing cystine or a salt thereof, as an active ingredient, is effective for improving exercise-induced gastrointestinal disorder, providing an improvement effect equal to or better than that by the conventional technology on exercise-induced gastrointestinal disorders including exercise-induced decline in gastrointestinal tract barrier function.
1. A method of reducing a risk of a gastrointestinal disorder induced by an exercise, comprising:
administering an effective amount of an agent containing cystine or a salt thereof as an active ingredient at least one time to a subject who does not have a gastrointestinal disorder; and
subjecting the subject to an exercise after the administration.
2. The method according to claim 1 , wherein said gastrointestinal disorder is at least one disorder selected from decline in gastrointestinal tract barrier function and gastrointestinal upset.
3. The method according to claim 1 , wherein a content of cystine or a salt thereof is not less than 0.1 wt % relative to the weight of all amino acids contained in said agent.
4. The method according to claim 1 , wherein said cystine or a salt thereof is in ingested in an amount of 6 mg to 12 g per one intake by a human.
5. The method according to claim 1 , further comprising ingesting at least one member selected from the group consisting of glutamine, a salt of glutamine, serine, a salt of serine, histidine, a salt of histidine, arginine, a salt of arginine, valine, a salt of valine, leucine, a salt of leucine, isoleucine, and a salt of isoleucine.
6. The method according to claim 5 , wherein a total of a content of said cystine or a salt thereof and a content of said at least one member selected from the group consisting of glutamine, a salt of glutamine, serine, a salt of serine, histidine, a salt of histidine, arginine, a salt of arginine, valine, a salt of valine, leucine, a salt of leucine, isoleucine, and a salt of isoleucine is not less than 10 wt % relative to the weight all amino acids contained in said agent.
7. The method according to claim 5 , wherein in said agent a weight ratio of (a) a content of said cystine or a salt thereof, and (b) a content of at least one member selected from the group consisting of glutamine, a salt of glutamine, serine, a salt of serine, histidine, a salt of histidine, arginine, a salt of arginine, valine, a salt of valine, leucine, a salt of leucine, isoleucine, and a salt of isoleucine is (a):(b)=1:0.01 to 10.
8. The method according to claim 1 , wherein said ingesting is oral ingestion.
9. The method according to claim 1 , further comprising:
administering said agent during the exercise or after completion of the exercise.
10. The method according to claim 1 , wherein said agent comprises cystine or a salt thereof in an amount of not less than 3 wt % relative to the weight of all amino acids contained in said agent.
11. The method according to claim 1 , wherein said agent further comprises glutamine or a salt of glutamine.
12. The method according to claim 1 , wherein said agent comprises cystine or a salt thereof in an amount of not less than 3 wt % relative to the weight of all amino acids contained in said agent, and said agent further comprises glutamine or a salt of glutamine.