Cleavable drug conjugates, compositions thereof and methods of use
Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.
1. A compound is selected from Formula (III-a), Formula (III-b), Formula (III-c), Formula (III-d), Formula (III-e), Formula (III-f), Formula (III-g), Formula (III-h), Formula (III-i), Formula (III-j), Formula (III-k), Formula (III-l), Formula (III-m), Formula (III-n), Formula (III-o), Formula (III-p), Formula (III-q), Formula (III-r), Formula (III-s), Formula (III-t), Formula (III-u), Formula (III-v), Formula (III-w), Formula (III-x), Formula (III-y), Formula (III-z), Formula (III-aa), Formula (III-ab), and Formula (III-ac), or a pharmaceutically acceptable salt of any of the foregoing:
2. A pharmaceutical composition comprising a pharmaceutically acceptable vehicle and at least one compound of claim 1 .
3. The pharmaceutical composition of claim 2 , comprising a therapeutically effective amount of the at least one compound of claim 1 .