IP Library Granted Patent US 10,907,129
Granted Patent B2
US 10,907,129 · App. 16/396,762 · Granted Feb 2, 2021

Apparatus for processing samples containing biological cells

Inventors: Matthias Opel (Jena, DE); David Unglaub (Neustadt/Orla, DE); Jens Eberhardt (Gera, DE); Gerd Bornmann (Weimar, DE)
Assignee: ALS Automated Lab Solutions GmbH
C12M45/02C12M29/06C12M33/04C12M37/02C12M41/14C12M41/18C12M45/06C12M45/20
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Quick Facts
Patent No.
US 10,907,129
App. No.
16/396,762
Granted
Feb 2, 2021
Kind
B2
Abstract

An apparatus and a method for the automated processing of samples containing biological cells—in particular, of blood samples or other cell samples is provided. The apparatus has a sample receiving device configured to receive samples, an auxiliary material receiving device configured to receive auxiliary materials, a sample carrier receiving device configured to receive sample carriers, a discharge device configured to discharge samples from a discharge position, and a capture device configured to capture discharged samples in a capture position to obtain prepared samples, and at least one temperature control device for controlling the temperature of at least one of the sample carriers. The distance between the discharge position and the capture position can be adjusted to a prespecified height. The method includes wetting a temperature-controlled sample carrier with at least one auxiliary material and discharging the sample onto the wetted temperature-controlled sample carrier from a prespecified height.

Claims (21)

1. An apparatus for the automated processing of a sample containing biological cells, the apparatus comprising:

a temperature-controlled storage area;

a working area;

a sample receiving device configured to receive the sample;

an auxiliary material receiving device configured to receive auxiliary materials;

a sample carrier receiving device configured to receive sample carriers;

a discharge device configured to discharge the sample from a discharge position;

at least one temperature control device configured to control a temperature of at least one of the sample carriers, and

a capture device configured to capture the sample discharged from the discharge position in a capture position to obtain a prepared sample, and a distance between the discharge position and the capture position being adjusted to a prespecified height of between 0.1 to 800 mm, the capture device having a holder configured to receive at least one of the sample carriers, said holder being configured such that the at least one sample carrier is arranged in the capture position to obtain the discharged sample.

2. The apparatus according to claim 1 , wherein the sample containing the biological cells is a blood sample or another cell sample.

3. The apparatus according to claim 1 , further comprising a housing in which components of the apparatus are arranged, wherein in the housing, physical and/or chemical conditions are set which differ from the conditions of the environment.

4. The apparatus according to claim 1 , wherein the discharge device includes a pipetting unit with a pipetting head movable at least along one axis.

5. The apparatus according to claim 1 , wherein the temperature-controlled storage area includes at least one of the auxiliary material receiving device and the sample carrier receiving device arranged therein.

6. The apparatus according to claim 1 , wherein the working area includes at least the discharge device and the capture device arranged therein.

7. The apparatus according to claim 1 , wherein:

the temperature controlled sample receiving device is arranged in the working area or in the storage area.

8. The apparatus according to claim 1 , further comprising a wetting device configured to wet the sample carriers with at least one of the auxiliary materials.

9. The apparatus according to claim 1 , further comprising an analysis unit configured to analyze the prepared sample.

10. The apparatus according to claim 1 , wherein:

the capture device has an actuator configured to adjust a prespecified angle of inclination of the at least one sample carrier, and

the angle of inclination of the at least one sample carrier is adjustable to a value between 0 and 90° relative to a horizontal plane.

Assignments (2)
CHANGE OF NAME Recorded Mar 29, 2024
From: ALS AUTOMATED LAB SOLUTIONS GMBH
To: SARTORIUS AUTOMATED LAB SOLUTIONS GMBH
Reel/Frame 066956/0509 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 7, 2019
From: OPEL, MATTHIAS; UNGLAUB, DAVID; EBERHARDT, JENS; BORNMANN, GERD
To: ALS AUTOMATED LAB SOLUTIONS GMBH
Reel/Frame 049682/0293 →
Priority Claims (1)
DE 10 2016 120 726 · Oct 28, 2016 · national
Continuity (2)
Continuation PCTDE2017100923 · Oct 28, 2017
Related Publication 20190249133A1 · Aug 15, 2019