Combinations with 2-aminoethanesulfonic acid
The invention relates to a pharmaceutical combination of 2-aminoethanesulfonic acid with a pharmaceutical agent such as an antihypertensive agent and the use of 2-aminoethanesulfonic acid in a method to lower the bilirubin level in the blood.
1. A pharmaceutical preparation for oral administration comprising 250-1000 mg 2-aminoethanesulfonic acid and an antihypertensive agent selected from the group consisting of telmisartan, irbesartan, valsartan, olmesartan, and azilsartan or a pharmaceutically acceptable salt thereof in admixture with one or more excipients selected from the group consisting of mannitol, sorbitol, xylitol, saccharose, calcium carbonate, calcium phosphate, lactose, croscarmellose sodium salt, crospovidone, sodium starch glycolate, hydroxypropylcellulose (low substituted), maize starch, polyvinylpyrrolidone, copolymers of vinylpyrrolidone with other vinyl derivatives, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, microcrystalline cellulose or starch, magnesium stearate, sodium stearyl fumarate, talc, hydroxypropylmethylcellulose, carboxymethylcellulose, cellulose acetate phthalate, polyvinylacetate, water, water/ethanol, water/glycerine, water/sorbitol, water/polyethylene glycol, propylene glycol, cetylstearyl alcohol, carboxymethylcellulose or substance containing fat.
2. The preparation according to claim 1 , characterized in that the preparation contains 20-200 mg of the angiotensin blocker telmisartan.
3. The preparation according to claim 1 , wherein the preparation is effective to lower the bilirubin level of a hypertensive individual having unconjugated hyperbilirubinemia.
4. The preparation according to claim 3 , wherein the preparation is effective to lower the bilirubin level of a hypertensive individual with an UGT1A1*28 allele.
5. The preparation according to claim 1 wherein the antihypertensive agent is irbesartan.
6. The preparation according to claim 1 wherein the antihypertensive agent is valsartan.
7. The preparation according to claim 1 wherein the antihypertensive agent is olmesartan.