Systems, devices, and methods for fluid monitoring
Devices, systems, and methods herein relate to predicting infection of a patient. These systems and methods may comprise illuminating a patient fluid in a fluid conduit from a plurality of illumination directions, measuring an optical characteristic of the illuminated patient fluid using one or more sensors, and predicting an infection state of the patient based at least in part on the measured optical characteristic.
1. A patient monitoring system, comprising:
a housing comprising:
a holder configured to releasably receive a portion of a fluid conduit;
a plurality of illumination sources configured to illuminate the received portion of the fluid conduit, the plurality of illumination sources comprising a first set of illumination sources arranged on a first sidewall of the holder; and
at least one optical sensor arranged on a second sidewall of the holder orthogonal to the first sidewall of the holder and configured to generate a signal,
wherein the holder comprises one or more engagement features configured to orient the received portion of the fluid conduit in a predetermined rotational and vertical orientation relative to the plurality of illumination sources and the at least one optical sensor, wherein the one or more engagement features defines an open slot arranged between the first sidewall and the second sidewall, and the open slot extending along a longitudinal axis of the holder.
2. The system of claim 1 , wherein the housing comprises a light seal.
3. The system of claim 1 , wherein the one or more engagement features is configured to orient the received portion of the fluid conduit by mating with an alignment feature of the received portion of the fluid conduit.
4. The system of claim 1 , wherein the at least one optical sensor comprises a first set of optical sensors and a second set of optical sensors, and the plurality of illumination sources comprise a second set of illumination sources,
the first set of illumination sources is arranged on the first sidewall orthogonal to the second set of illumination sources arranged on the second sidewall, and
the first set of optical sensors is arranged on a third sidewall of the holder orthogonal to the first set of illumination sources arranged on the first sidewall, and
the second set of optical sensors is arranged on a fourth sidewall of the holder orthogonal to the second set of illumination sources arranged on the second sidewall of the holder.
5. The system of claim 1 , wherein the at least one optical sensor comprises a first set of optical sensors and a second set of optical sensors, and the plurality of illumination sources comprise a second set of illumination sources,
the first set of illumination sources is arranged on the first sidewall opposite to the second set of illumination sources arranged on the second sidewall, and
the first set of optical sensors is arranged on a third sidewall of the holder orthogonal to the first set of illumination sources arranged on the first sidewall, and
the second set of optical sensors is arranged on a fourth sidewall of the holder orthogonal to the second set of illumination sources arranged on the second sidewall.
6. The system of claim 1 , wherein at least two of the plurality of illumination sources are disposed in a first plane and are configured to illuminate at a first wavelength.
7. The system of claim 6 , wherein at least another two of the plurality of illumination sources are disposed in a second plane substantially parallel to the first plane.
8. The system of claim 1 , wherein the plurality of illumination sources comprise a first illumination source configured to emit light at a first wavelength between about 820 nm and about 900 nm.
9. The system of claim 1 , wherein the plurality of illumination sources comprise a second illumination source configured to emit light at a second wavelength between about 400 nm and about 450 nm.
10. The system of claim 1 , wherein the plurality of illumination sources comprise a third illumination source configured to emit light at a third wavelength between about 500 nm and about 550 nm.
11. The system of claim 1 , wherein the plurality of illumination sources comprise a fourth illumination source configured to emit light at a fourth wavelength between about 230 nm and about 290 nm.
12. The system of claim 1 , wherein the at least one optical sensor comprises a plurality of optical sensors spaced apart parallel to the longitudinal axis.
13. The system of claim 1 , wherein the housing comprises one or more collimators comprising.
14. The system of claim 1 , wherein the housing comprises a peritoneal dialysis device fluid path.
15. The system of claim 1 , wherein the fluid conduit is coupled to one or more of a peritoneal dialysis tubing set and a peritoneal dialysis drain bag connector.
16. The system of claim 1 , wherein the fluid conduit is coupled to a peritoneal dialysis cycler tubing set.
17. The system of claim 1 , wherein the fluid conduit comprises:
an inlet portion;
an outlet portion; and
an optically transparent measurement portion between the inlet portion and the outlet portion, wherein the measurement portion comprises at least two substantially planar surfaces, a rotational alignment feature, and a depth alignment feature.
18. The system of claim 17 , wherein at least one of the rotational alignment feature and the depth alignment feature is configured to mate with the one or more engagement features of the holder.
19. The system of claim 1 , further comprising a controller configured to generate patient data based at least in part on the signal.
20. The system of claim 19 , wherein the controller is located remote from the housing, and wherein the system further comprises a communication device configured to transmit data representative of signal to the controller.
21. The system of claim 20 , wherein the controller is configured to monitor a trend in infection score predicting infection resolution of the patient.
22. The system of claim 21 , wherein the controller is configured to estimate fluid flow rate in the fluid conduit based at least in part on the patient data, wherein illuminating the patient fluid comprises activating illumination in response to the estimated fluid flow rate.
23. The system of claim 20 , wherein the controller is configured to monitor a trend in infection score predicting infection resolution of the patient by predicting infection resolution in response to any one or more of the following: the infection score falling below a predetermined threshold during each of one or more successive measurement time periods, the infection score decreasing from a patient baseline over time, and the infection score having a decreasing rate of change over time.
24. The system of claim 19 , wherein the controller is configured to predict an infection score of a patient based at least in part on the signal.
25. The system of claim 24 , wherein the controller is configured to predict an infection state of a patient in response to any one or more of the following: the infection score exceeding a predetermined threshold during each of one or more successive measurement time periods, the infection score increasing from a patient baseline over time, and the infection score having an increasing rate of change over time.
26. The system of claim 25 , wherein the infection state comprises a probability of infection.
27. The system of claim 24 , wherein the fluid conduit is configured to receive a patient fluid and the controller is configured to estimate turbidity of the patient fluid based at least in part on the signal, wherein the infection score is based at least in part on the estimated turbidity.