IP Library › Granted Patent US 10,927,082
Granted Patent B2
US 10,927,082 · App. 16/886,642 · Granted Feb 23, 2021

Farnesoid X receptor agonists and uses thereof

Inventors: Nicholas D. Smith (San Diego, CA); Stephen P. Govek (San Diego, CA); Johnny Y. Nagasawa (San Diego, CA)
Assignee: METACRINE, INC.
C07D231/12A61K9/0014A61K9/0029A61K9/0053A61K9/06A61K9/2054A61K9/4866A61P1/00A61P1/16C07D401/04C07D401/14C07D403/12C07D405/12C07D471/04
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Quick Facts
Patent No.
US 10,927,082
App. No.
16/886,642
Granted
Feb 23, 2021
Kind
B2
Abstract

Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Claims (4)

1. A compound that has the following structure:

or a pharmaceutically acceptable salt, or solvate thereof.

2. A pharmaceutical composition comprising a compound that has the following structure:

or a pharmaceutically acceptable salt, or solvate thereof; and at least one pharmaceutically acceptable excipient.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 21, 2025
From: ORGANOVO, INC.
To: ELI LILLY AND COMPANY
Reel/Frame 070892/0218 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 18, 2023
From: METACRINE, INC.
To: ORGANOVO, INC.
Reel/Frame 063354/0856 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2020
From: SMITH, NICHOLAS D.; GOVEK, STEVEN P.; NAGASAWA, JOHNNY Y.
To: METACRINE, INC.
Reel/Frame 052883/0227 →
Continuity (3)
Continuation 16494264
Provisional Application 62471517 · Mar 15, 2017
Related Publication 20200290973A1 · Sep 17, 2020