Bottlebrush polymer compositions, lubricating fluid, porous materials comprising said compositions, and surface bearing said compositions
A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.
1. A lubricating fluid comprising:
a. a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:
and
b. a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof,
the bottle-brush polymer and the linear polymer being dissolved together in a solvent.
2. The lubricating fluid according to claim 1 , wherein the linear polymer is partially crosslinked.
3. The lubricating fluid according to claim 1 , comprising the bottle-brush polymer and the linear polymer in a bottle-brush polymer:linear polymer weight ratio between about 1:1 and about 1:20.
4. The lubricating fluid according to claim 1 , wherein the bottle-brush polymer has a grafting ratio between about 40% and about 60%.
5. The lubricating fluid according to claim 1 , wherein the molecular weight of the backbone is between about 10 kDa and about 100 kDa.
6. The lubricating fluid according to claim 1 , wherein the molecular weight of the pendant chain is between about 1 kDa and about 15 kDa.
7. The lubricating fluid according to claim 1 , wherein the concentration of the bottle-brush polymer in the lubricating fluid is between about 1 ug/ml and about 0.1 mg/mL.
8. The lubricating fluid according to claim 1 , wherein the linear polymer has a molecular weight between about 5 kDa and or about 5 MDa.
9. The lubricating fluid according to claim 1 , wherein the concentration of linear polymer in the lubricating fluid is between about 0.001 mg/mL and about 0.01 mg/mL.
10. The lubricating fluid according to claim 1 , wherein the solvent is saline.
11. A surface bearing a polymeric layer, the polymeric layer comprising:
a. a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:
and
b. a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof.
12. The surface of claim 11 , being a surface of an ophthalmic lens, a surface of the barrel of a syringe, a surface of an injection device, a surface of an elution device, or a surface of an implant.
13. The surface of claim 12 , where the surface is a surface of a contact lens.
14. The surface of claim 11 , wherein the polymeric layer releases the bottle-brush polymer and the linear polymer when the surface contacts a solvent.
15. A porous material having embedded therein:
a. a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:
and
b. a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof.
16. The porous material of claim 15 , wherein the porous material is a gel, a sponge, a textile or textile fibers.
17. The porous material of claim 15 , wherein the porous material is a contact lens.