IP Library › Granted Patent US 10,941,145
Granted Patent B2
US 10,941,145 · App. 16/890,765 · Granted Mar 9, 2021

Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor

Inventors: Yam B. Poudel (Fremont, CA); Sanjeev Gangwar (Foster City, CA); Prasanna Sivaprakasam (Lawrenceville, NJ); Shoshana L. Posy (Highland Park, NJ)
Assignee: Bristol-Myers Squibb Company
C07D473/18A61P37/04
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Quick Facts
Patent No.
US 10,941,145
App. No.
16/890,765
Granted
Mar 9, 2021
Kind
B2
Abstract

Compounds having a structure according to formula (I) where R 1 , R 2 , and R 3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

Claims (1)

1. A compound having a structure according to formula (Ia-05)

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2020
From: POUDEL, YAM B.; GANGWAR, SANJEEV; SIVAPRAKASAM, PRASANNA; POSY, SHOSHANA L.
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 053885/0713 →
Continuity (4)
Continuation 16583869 · Sep 26, 2019
Continuation 16103210 · Aug 14, 2018
Provisional Application 62546095 · Aug 16, 2017
Related Publication 20200291028A1 · Sep 17, 2020