Curcumin-based compositions and methods of use thereof
View Patent ↗Methods and compositions for increasing LDL receptor levels in a plurality of cells are disclosed. For example, the methods include providing to the cells a curcumin composition that is at least 15% curcumin II or at least 5% curcumin III, in order to increase LDL receptor levels. In addition, compositions for increasing LDL receptor levels in a plurality of cells are disclosed, which include a curcumin composition consisting of at least 15% curcumin II or at least 5% curcumin III (or combinations of such curcuminoids), along with a pharmaceutically-acceptable solvent, filler, or carrier. Still further, methods and compositions for decreasing MSK1 levels in a plurality of cells are disclosed, which involve administering a curcumin III-enriched composition to the cells.
1. A composition that comprises:
(a) 30-40% curcumin I;
(b) 9-11% curcumin II; and
(c) 45%-55% curcumin III, wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.
2. The composition of claim 1 , which comprises about 35% curcumin I, about 10% curcumin II, and about 50% curcumin III.
3. The composition of claim 1 , wherein the composition is formulated as the capsule, which further comprises hydroxypropyl methylcellulose, water, microcrystalline cellulose, magnesium stearate, and silicon dioxide.
4. A composition that comprises:
(a) 45-55% curcumin I;
(b) 10-20% curcumin II; and
(c) 20%-40% curcumin III, wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.
5. The composition of claim 4 , which comprises about 50% curcumin I, about 15% curcumin II, and about 30% curcumin III.
6. The composition of claim 4 , wherein the composition is formulated as the capsule, which further comprises hydroxypropyl methylcellulose, water, microcrystalline cellulose, magnesium stearate, and silicon dioxide.
7. A composition that comprises a curcumin extract, which is supplemented with additional (a) curcumin II, (b) curcumin III, or (c) both curcumin II and curcumin III, such that the composition comprises:
(i) at least 50% curcumin II; or
(ii) at least 50% curcumin III,
wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.