Treatment and diagnosis of melanoma
The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
1. A method of treating non-small cell lung cancer in a subject in need thereof, the method comprising administering to the subject compound 25, or a pharmaceutically acceptable salt thereof, one of cisplatin and carboplatin, pemetrexed, and a PD- 1 inhibitor in amounts which together are effective, wherein compound 25 is represented as follows
2. The method of claim 1 , wherein the non-small cell lung cancer is resistant to a kinase inhibitor, a PD- 1 inhibitor, and/or a PD-L 1 inhibitor.
3. The method of claim 1 , wherein the non-small cell lung cancer progressed on or after treatment with a kinase inhibitor, a PD- 1 inhibitor, and/or a PD-L 1 inhibitor.
4. The method of claim 1 , wherein the non-small cell lung cancer has been determined to be, or is predicted to be, resistant to a kinase inhibitor, a PD- 1 inhibitor, and/or a PD-L 1 inhibitor.
5. The method of claim 1 , wherein the non-small cell lung cancer is metastatic.
6. The method of claim 1 , wherein the non-small cell lung cancer has been diagnosed as metastatic.
7. The method of claim 1 , wherein the effective amount is an amount effective to suppress metastatic progression of the non-small cell lung cancer.
8. The method of claim 1 , wherein the one of cisplatin and carboplatin is cisplatin.
9. The method of claim 1 , wherein the one of cisplatin and carboplatin is carboplatin.