Method and system for evaluation of functional cardiac electrophysiology
An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.
1. A method of treating an individual with a cardiac arrhythmia, the method comprising:
(a)measuring at least one magnetic field data associated with a heart of the individual;
(b) translating the at least one magnetic field data to at least one current density value of the heart of the individual;
(c) graphically combining the at least one current density value with a radiographic image of a heart to generate a current density map of the heart of the individual, wherein the current density map visually displays the at least one current density value in an arrangement that represents an anatomically correct configuration of a heart;
(d) identifying a region of the current density map associated with the cardiac arrhythmia; and
(e) ablating the heart at a location corresponding to the region.
2. The method of claim 1 , wherein the current density map is non-invasively generated.
3. The method of claim 1 , wherein graphically combining the at least one current density value with the radiographic image of the heart comprises overlaying the at least one current density value onto the radiographic image of the heart.
4. The method of claim 3 , wherein the at least one current density value is represented by an icon positioned at a spatial location of the current density map corresponding to an associated anatomical position of the heart of the individual.
5. The method of claim 1 , wherein the cardiac arrhythmia comprises atrial fibrillation.
6. The method of claim 1 , wherein the current density map comprises a three-dimensional image.
7. The method of claim 1 , wherein the current density map comprises a plurality of distributed, spatially accurate electrical current values having dynamic, real-time parameters.
8. The method of claim 1 , wherein the radiographic image comprises a two-dimensional X-ray image.
9. The method of claim 1 , wherein the radiographic image comprises a computed tomography (CT) scan.
10. The method of claim 1 , wherein the radiographic image comprises a three-dimensional image.
11. The method of claim 10 , wherein the three-dimensional image is generated from two or more two-dimensional X-ray images.
12. The method of claim 1 , further comprising receiving demographic data associated with the individual.
13. The method of claim 12 , wherein the demographic data comprises one or more of age, race, gender, and medical history of the individual.
14. The method of claim 13 , further comprising using the received demographic data associated with the individual to identify an image of a heart of a different individual, wherein the demographic data associated with the individual and demographic data associated with the different individual are essentially identical in the one or more of the age, the race, the gender, and the medical history.
15. The method of claim 14 , wherein the radiographic image comprises the image of the heart of the different individual.
16. The method of claim 1 , further comprising receiving biometric data associated with the individual, and identifying the region of the current density map associated with the cardiac arrhythmia based at least in part on the biometric data.
17. The method of claim 16 , wherein the biometric data comprises one or more of a heart rate, a heart rate variability, a blood pressure, a temperature, an activity level, and an electrocardiogram of the individual.
18. The method of claim 1 , further comprising receiving physiological data associated with the individual, and identifying the region of the current density map associated with the cardiac arrhythmia based at least in part on the physiological data.
19. The method of claim 18 , wherein the physiological data comprises one or more of electroencephalogram (EEG) data and electrocardiogram (ECG) data.
20. The method of claim 1 , further comprising measuring the at least one magnetic field data associated with the heart of the individual using at least one electromagnetic sensor configured to sense a magnetic field associated with a heart of an individual.
21. The method of claim 20 , wherein the at least one electromagnetic sensor comprises one or more of a Superconducting Quantum Interference Device (SQUID) and an atomic magnetometer.
22. The method of claim 1 , wherein translating the at least one magnetic field data to the at least one current density value comprises applying one or more of a Fourier transform, a Radon transform, and a Penrose transform to the at least one magnetic field data.
23. The method of claim 1 , wherein the radiographic image comprises an image of the heart of the individual.