Ophthalmic composition
Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment of an ophthalmic disorder or condition; and an ophthalmically acceptable carrier, wherein the ophthalmic agent is distributed with substantial uniformity throughout the ophthalmically acceptable carrier. Further disclosed herein include an ophthalmic composition including a low concentration of an ophthalmic agent and deuterated water. Also disclosed herein are methods of arresting or preventing myopia development by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.
1. A pharmaceutical composition comprising:
a. about 0.01 mg/g to about 0.5 mg/g of atropine or atropine sulfate; and
b. a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is free of preservative.
2. The pharmaceutical composition of claim 1 , wherein the atropine or atropine sulfate is present in the pharmaceutical composition at a concentration of from about 0.01 mg/g to about 0.3 mg/g or from about 0.1 mg/g to about 0.2 mg/g.
3. The pharmaceutical composition of claim 1 , wherein the atropine or atropine sulfate is present in the pharmaceutical composition at a concentration of about 0.1 mg/g, about 0.2 mg/g, about 0.25 mg/g, about 0.3 mg/g, about 0.4 mg/g, or about 0.5 mg/g.
4. The pharmaceutical composition of claim 1 , further comprising a buffering agent.
5. The pharmaceutical composition of claim 4 , wherein the buffering agent comprises a borate, a borate-polyol complex, a phosphate buffering agent, a citrate buffering agent, an acetate buffering agent, a carbonate buffering agent, an organic buffering agent, an amino acid buffering agent, or a combination thereof.
6. The pharmaceutical composition of claim 4 , wherein the buffering agent comprises sodium dihydrogen phosphate, disodium hydrogen phosphate, or a combination thereof.
7. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a tonicity adjusting agent.
8. The pharmaceutical composition of claim 7 , wherein the tonicity adjusting agent comprises a halide salt of a monovalent cation.
9. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a viscosity agent.
10. The pharmaceutical composition of claim 9 , wherein the viscosity agent comprises hydroxyethyl cellulose, hydroxypropyl cellulose, or hydroxypropylmethylcellulose (HPMC).
11. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is essentially free of procaine and benactyzine, or pharmaceutically acceptable salts thereof.
12. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a pH of from about 3.8 to about 6.4.
13. The pharmaceutical composition of claim 1 , wherein the pharmaceutically acceptable carrier comprises water.
14. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is acidic.
15. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has a pH of less than 5.