Triggerable shape memory induction devices
In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions described herein comprise a triggerable shape memory polymer network. In certain embodiments, the polymer network comprises a covalently crosslinked polymeric material and a non-crosslinked polymeric material associated with the crosslinked polymeric material. In some cases, the polymer network has a first configuration (e.g., as polymerized), and a second configuration (e.g., upon heating and deformation), such that the polymer network can be triggered to recover the first configuration upon heating the polymeric material above a softening temperature of the polymeric material. In certain embodiments, the polymer network comprises a plurality of particles capable of increasing the temperature of the polymer network (e.g., above the softening temperature) in the presence of an external stimulus such as induction, radio frequency, or magnetic resonance, such that the polymer network changes configuration. The polymeric material may be molded into any suitable shape.
1. A method for removing a device from a location internally of a subject, comprising:
stimulating the device such that the device obtains a second configuration, wherein the second configuration is sufficiently small such that the device is removed from the location internally of the subject;
wherein the device has a first configuration different than the second configuration prior to stimulating;
wherein the second configuration has a largest cross-sectional dimension at least about 10% less than a largest cross-sectional dimension of the first configuration, and/or
wherein the second configuration has a convex hull at least about 10% less than a convex hull of the first configuration;
wherein the device comprises a triggerable shape memory composition, the triggerable shape memory composition comprising:
a polymer network comprising a first polymeric material and a second polymeric material; and
a plurality of paramagnetic particles associated with the polymer network;
wherein the first polymeric material is a non-crosslinked polymer having a softening temperature of greater than or equal to about 45° C.;
wherein the second polymeric material is a crosslinked polymer;
wherein the polymer network is constructed and arranged to have a first configuration below the softening temperature of the first polymeric material and a second configuration different than the first configuration above the softening temperature of the first polymeric material; and
wherein the second configuration has a largest cross-sectional dimension at least about 10% less than a largest cross-sectional dimension of the first configuration and/or
wherein the second configuration has a convex hull at least about 10% less than a convex hull of the first configuration.
2. A method for selectively retaining a device in a location internally of a subject, comprising:
administering the device, wherein the device has a first configuration, wherein the device obtains a second configuration in the location internally of the subject such that the device is retained within the location;
stimulating, after a period of time, the device such that the device obtains the first configuration, wherein the first configuration is such that device is removed from the location;
wherein the device comprises a triggerable shape memory composition, the triggerable shape memory composition comprising:
a polymer network comprising a first polymeric material and a second polymeric material; and
a plurality of paramagnetic particles associated with the polymer network;
wherein the first polymeric material is a non-crosslinked polymer having a softening temperature of greater than or equal to about 45° C.;
wherein the second polymeric material is a crosslinked polymer;
wherein the polymer network is constructed and arranged to have a first configuration below the softening temperature of the first polymeric material and a second configuration different than the first configuration above the softening temperature of the first polymeric material; and
wherein the second configuration has a largest cross-sectional dimension at least about 10% less than a largest cross-sectional dimension of the first configuration and/or
wherein the second configuration has a convex hull at least about 10% less than a convex hull of the first configuration.
3. A method as in claim 2 , wherein the device is administered orally.
4. A method as in claim 2 , wherein the device is contained within a capsule prior to and/or during administering the device.
5. A method as in claim 2 , wherein stimulating the device comprises applying an external signal to the subject.
6. A method as in claim 2 , wherein stimulating the device comprises heating the device.
7. A method as in claim 2 , wherein stimulating the device comprises induction.
8. A method as in claim 2 , wherein the device is heated to a temperature ranging between 45° C. and 65° C., inclusive.
9. A method as in claim 2 , wherein the device comprises a polymer network having a softening temperature ranging between 45° C. and 65° C., inclusive.
10. A triggerable retention device for controlled retention internally of a subject, comprising:
an expanded profile in which the device, when positioned at a location internally of the subject, is retained at that location, the device being susceptible to a stimulus applied from externally of the subject whereby the device assumes a contracted profile and is eliminated from the location internally of the subject,
wherein the device comprises a triggerable shape memory composition, the triggerable shape memory composition comprising:
a polymer network comprising a first polymeric material and a second polymeric material; and
a plurality of paramagnetic particles associated with the polymer network;
wherein the first polymeric material is a non-crosslinked polymer having a softening temperature of greater than or equal to about 45° C.;
wherein the second polymeric material is a crosslinked polymer;
wherein the polymer network is constructed and arranged to have a first configuration below the softening temperature of the first polymeric material and a second configuration different than the first configuration above the softening temperature of the first polymeric material; and
wherein the second configuration has a largest cross-sectional dimension at least about 10% less than a largest cross-sectional dimension of the first configuration and/or
wherein the second configuration has a convex hull at least about 10% less than a convex hull of the first configuration.
11. A device as in claim 10 , wherein the first polymeric material and/or second polymeric material comprises polycaprolactone and/or polylactic acid.
12. A device as in claim 10 , wherein the location internal of the subject is within the gastrointestinal tract.
13. A triggerable retention device as in claim 10 , wherein the device comprises a triggerable shape memory composition, the triggerable shape memory composition comprising:
a polymer network comprising a first polymeric material and a second polymeric material;
a plurality of non-polymeric portions associated with the polymer network which, upon exposure to the external stimulus, facilitate heating of the first polymeric material to at least about 45° C.;
wherein the first polymeric material has a softening temperature of greater than or equal to about 45° C.;
wherein the polymer network is constructed and arranged to have a first configuration below the softening temperature of the first polymeric material and a second configuration different than the first configuration above the softening temperature of the first polymeric material; and
wherein the second configuration has a largest cross-sectional dimension at least about 10% less than a largest cross-sectional dimension of the first configuration and/or
wherein the second configuration has a convex hull at least about 10% less than a convex hull of the first configuration.
14. A triggerable retention device as in claim 10 , wherein the plurality of non-polymeric portions comprise paramagnetic particles.
15. A triggerable retention device as in claim 10 , wherein the softening temperature is a glass transition temperature of the first polymeric material.
16. A triggerable retention device as in claim 10 , wherein the softening temperature is a melting temperature of the first polymeric material.
17. A triggerable retention device as in claim 10 , wherein the second polymeric material has a softening temperature greater than the softening temperature of the first polymeric material.
18. A triggerable retention device as in claim 10 , wherein the polymeric material comprises polycaprolactone and/or polylactic acid.
19. A triggerable retention device for controlled retention internally of a subject, comprising:
an expanded profile in which the device, when positioned at a location internally of the subject, is retained at that location under normal physiological conditions, the device being susceptible to a stimulus applied from externally of the subject whereby the device assumes a contracted profile and is eliminated from the location internally of the subject,
wherein the device comprises a triggerable shape memory composition, the triggerable shape memory composition comprising:
a polymer network comprising a first polymeric material and a second polymeric material;
a plurality of non-polymeric portions associated with the polymer network which, upon exposure to an external stimulus, facilitate heating of the first polymeric material to at least about 45° C.;
wherein the first polymeric material has a softening temperature of greater than or equal to about 45° C.;
wherein the polymer network is constructed and arranged to have a first configuration below the softening temperature of the first polymeric material and a second configuration different than the first configuration above the softening temperature of the first polymeric material; and
wherein the second configuration has a largest cross-sectional dimension at least about 10% less than a largest cross-sectional dimension of the first configuration and/or
wherein the second configuration has a convex hull at least about 10% less than a convex hull of the first configuration.