Nano-pore arrays for bio-medical, environmental, and industrial sorting, filtering, monitoring, or dispensing
Micro- or nano-pores are produced in a membrane for various applications including filtration and sorting functions. Pores with at least one cross-sectional dimension in or near the nano-scale are provided. Device designs and processing allow for the use of thin film disposition and nano-imprinting or nano-molding to produce arrays of nano-pores in membrane materials functioning in applications such as filtration membranes, drug application/control structures, body fluid sampling structures, and sorting membranes. The nano-imprinting or nano-molding approach is utilized to create nano-elements in an organic or inorganic mold material with at least one nano-element cross-sectional dimension in or close to the nano-scale. These nano-elements can be in various shapes including slits, cones, columns, domes, and hemispheres.
1. A process for the formation of a pore array, the pore array comprising at least one pore having at least one cross-sectional dimension of from 0.2 to 1000 nanometers, the process comprising:
providing an organic or inorganic material substrate with a nano-element array having positive nano-elements, the positive nano-elements being protrusions of the material of a height h;
coating the substrate with a coating layer;
disposing a membrane material of a thickness t less than h on the substrate such that the membrane material is disposed among the positive nano-elements and the thickness t of the membrane material is kept below the height h;
removing the coating layer from the positive nano-elements above the thickness t of the membrane material using etching or chemo-mechanical polishing (CMP);
separating said substrate from the membrane material and the coating layer using dissolution, etching or CMP thereby creating a coated membrane having a pore array with at least one pore in the membrane material, the pore array with the at least one pore having the cross sectional dimension of 0.2 to 1000 nanometers.
2. The process of claim 1 , wherein said coating layer controls pore cross-sectional dimensions.
3. The process of claim 1 , wherein said coating layer is comprised of at least a SAM material or an ALD material.
4. The process of claim 1 , wherein an exposed area of said coating layer is at least partially comprised of a functionalizing layer incorporating at least one of RNA, double stranded DNA, single stranded DNA, peptides, proteins, antibodies, or antigens.
5. The process of claim 1 , wherein the composition of said coating layer is a conductor or semiconductor.
6. The process of claim 5 , further comprising disposing an insulator layer upon the conductor or semiconductor layer.
7. The process of claim 1 , wherein said coating layer controls at least the property of pore dimensionality, pore transport, or specificity.
8. The process of claim 1 , further comprising biasing said coating layer with respect to a surrounding media to control one or more of pore effective size, pore flow properties, selectivity, fouling control, and nano-structure positioning.
9. The process of claim 1 , wherein the membrane material is a fluid or a precursor of the membrane material is a fluid.